Results 271 to 280 of about 9,911,867 (381)

Proteome profiling outperforms transcriptome profiling for coexpression based gene function prediction [PDF]

, 2017
et al.,, Townsend, R. Reid
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Gene Prediction by Spectral Rotation Measure: A New Method for Identifying Protein-Coding Regions [PDF]

, 2003
Daniel Kotlar, Yizhar Lavner
openalex   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

BenchAMRking: a Galaxy-based platform for illustrating the major issues associated with current antimicrobial resistance (AMR) gene prediction workflows. [PDF]

BMC Genomics
Strepis N, Dollee D, Vrins D, Vanneste K, Bogaerts B, Carrillo C, Bharat A, Horan K, Sherry NL, Seemann T, Howden BP, Hiltemann S, Chindelevitch L, Stubbs AP, Hays JP.   +14 more
europepmc   +1 more source

Ancestry may confound genetic machine learning: Candidate-gene prediction of opioid use disorder as an example. [PDF]

Drug Alcohol Depend, 2021
Hatoum AS, Wendt FR, Galimberti M, Polimanti R, Neale B, Kranzler HR, Gelernter J, Edenberg HJ, Agrawal A.   +8 more
europepmc   +1 more source

Prediction of the Coding Sequences of Mouse Homologues of KIAA Gene: II. The Complete Nucleotide Sequences of 400 Mouse KIAA-homologous cDNAs Identified by Screening of Terminal Sequences of cDNA Clones Randomly Sampled from Size-fractionated Libraries [PDF]

, 2003
N. Okazaki
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Ensemble decision of local similarity indices on the biological network for disease related gene prediction. [PDF]

PeerJ
Cingiz MÖ.
europepmc   +1 more source

No one tool to rule them all: prokaryotic gene prediction tool annotations are highly dependent on the organism of study. [PDF]

Bioinformatics, 2022
Dimonaco NJ, Aubrey W, Kenobi K, Clare A, Creevey CJ.   +4 more
europepmc   +1 more source