Results 91 to 100 of about 2,805,831 (274)
Prioritization and comprehensive analysis of genes associated with melanoma
Oncology Letters, 2019 Melanoma is a malignant tumor derived from melanocytes, which occurs mostly in the skin. A major challenge in cancer research is the biological interpretation of the complexity of cancer somatic mutation profiles. The aim of the present study was to obtain a comprehensive understanding of the formation and development of melanoma and to identify its ...
Feng, C +4 more
openaire +4 more sources
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Improved human disease candidate gene prioritization using mouse phenotype
BMC Bioinformatics, 2007 Background The majority of common diseases are multi-factorial and modified by genetically and mechanistically complex polygenic interactions and environmental factors.
Aronow Bruce J +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
wiley +1 more source
GeneTIER: prioritization of candidate disease genes using tissue-specific gene expression profiles. [PDF]
, 2015 Motivation In attempts to determine the genetic causes of human disease, researchers are often faced with a large number of candidate genes. Linkage studies can point to a genomic region containing hundreds of genes, while the high-throughput sequencing ...
Daly, C +6 more
core +1 more source
MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis
FEBS Open Bio, EarlyView.MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss +7 more
wiley +1 more source
Incorporation of Knowledge for Network-based Candidate Gene Prioritization [PDF]
, 2012 In order to identify the genes associated with a given disease, a number of different high-throughput techniques are available such as gene expression profiles.
Kimmel, Chad
core
Gene prioritization of resistant rice gene against Xanthomas oryzae pv. oryzae by using text mining technologies [PDF]
, 2020 To effectively assess the possibility of the unknown rice protein resistant to Xanthomonas oryzae pv. oryzae, a hybrid strategy is proposed to enhance gene prioritization by combining text mining technologies with a sequence-based approach.
Alex Chengyu Fang +5 more
core
FEBS Open Bio, EarlyView.Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo +4 more
wiley +1 more source
PRIORI-T: A tool for rare disease gene prioritization using MEDLINE - Fig 1
, 2020 PRIORI-modules: (a) Rare Disease Dictionary Curation module, (b) Rare Disease Annotator (c) Rare Disease MEDLINE Processor (d) Network Creation module (e) Gene Prioritization module.
Rajgopal Srinivasan (5489906) +5 more
core +1 more source