Results 141 to 150 of about 2,805,831 (274)

Hybrid Biofabrication of a Hierarchically Organized Periosteum‐Inspired In Vitro Platform

Advanced Healthcare Materials, EarlyView.
A hybrid biofabrication strategy integrates melt electrowriting with extrusion‐based 3D bioprinting to create a hierarchically organized periosteum‐inspired in vitro platform. Spatially defined osteogenic, fibrous, and endothelial cell‐containing compartments support long‐term culture, osteogenic maturation, and CD31+ endothelial cell organization ...
Yakui Liu, Xinggui Tian, Anne Bernhardt, Anja Lode, Max von Witzleben, Ege Kirbas, Stefan Zwingenberger, Michael Gelinsky   +7 more
wiley   +1 more source

Multi-region transcriptomics and unsupervised clustering reveal recurrent and region-specific gene signatures in Alzheimer’s disease

IBRO Neuroscience Reports
Alzheimer’s disease (AD) exhibits anatomically heterogeneous transcriptomic alterations, complicating the identification of disease-associated genes with consistent external support.
Zohre Moattar-Husseini, Abbas Ahmadi, Nafiseh Mohebi   +2 more
doaj   +1 more source

Bone Organoids Across the Development‐to‐Remodeling Continuum: From Tissue Formation to Functional Competence and Translation

Advanced Healthcare Materials, EarlyView.
Mineralization alone does not establish a mature bone organoid. This Review integrates biological foundations, materials design, adaptive remodeling, and translational validation through the development‐to‐remodeling continuum (DRC). By separating biological functions from the evidence supporting them, the framework exposes critical gaps in current ...
Xijie Tang, Haijia Xu, Xiangzhong Liu, Yi Yang, Zhanghua Li   +4 more
wiley   +1 more source

Bioprinted Stiffness‑Tunable Pancreatic Microniches to Decode Early Tumor Initiation Mechanisms

Advanced Healthcare Materials, EarlyView.
Stiffness‐tunable GelMA microniches generated by microvalve bioprinting preserve wild‐type acinar identity while revealing a nonlinear, Kras‐dependent response to matrix mechanics. Intermediate stiffness promotes acinar‐to‐ductal metaplasia and proliferation, defining a permissive mechanical window.
Aurelien Mazet, Charles Handschin, Theo Desigaux, Nathalie Dusserre, Marie‐Laure Stachowicz, Shane Fennell, Malou Lea, Silvia Arcucci, Benoît Thibault, Jean‐Christophe Fricain, Julie Guillermet‐Guibert, Hugo Oliveira   +11 more
wiley   +1 more source

Prioritizing questions and topics for the development of guidelines and consensus-based recommendations supported by ILAE: a scoping review and proposal of prioritization criteria [PDF]

Clinical practice guidelines (CPGs) and consensus-based recommendations (CBRs) require considerable effort, collaboration, and time—all within the constraints of finite resources. Professional societies, such as the International League Against Epilepsy (

core   +1 more source

Organic Materials of Tomorrow: Horizons of Artificial Intelligence

Advanced Materials, EarlyView.
This review examines machine learning techniques accelerating the discovery of organic semiconductors by linking molecular structure to properties. Key methods include graph neural networks, generative models, and active learning. Applications to organic photovoltaics demonstrate practical impact.
Harold Mena, J. Terence Blaskovits, Kun‐Han Lin, Denis Andrienko   +3 more
wiley   +1 more source

Radiative Thermal Management for Extreme Environments: Mechanisms and Design Strategies

Advanced Materials, EarlyView.
In this review, we discuss the fundamental mechanisms of radiative cooling and solar heating, material and structural design strategies, hybrid approaches integrating additional heat transfer pathways, and durability‐oriented designs addressing environmental stresses.
Hyung Rae Kim, Haeseong Kim, Joo Hwan Ko, Gil Ju Lee, Dae‐Hyeong Kim, Young Min Song   +5 more
wiley   +1 more source

Harnessing large language models (LLMs) for candidate gene prioritization and selection. [PDF]

J Transl Med, 2023
Toufiq M, Rinchai D, Bettacchioli E, Kabeer BSA, Khan T, Subba B, White O, Yurieva M, George J, Jourde-Chiche N, Chiche L, Palucka K, Chaussabel D.   +12 more
europepmc   +1 more source

GPSy: a cross-species gene prioritization system for conserved biological processes--application in male gamete development.

, 2012
International audienceWe present gene prioritization system (GPSy), a cross-species gene prioritization system that facilitates the arduous but critical task of prioritizing genes for follow-up functional analyses.
Chalmel, Frédéric, Britto, Ramona, Michaux, Grégoire, Primig, Michael, Sallou, Olivier, Collin, Olivier   +5 more
core   +1 more source

Biomass DNA: An Emerging Building Block for Advanced Materials

Advanced Materials, EarlyView.
Biomass DNA is rapidly emerging from its traditional role as a genetic blueprint to serve as a versatile abundant, highly programmable polymeric building block. This review highlights the transformation of macroscopic bulk biomass DNA into next generation of functional materials, spanning from dynamic hydrogels, sustainable bioplastics, and high ...
Yuwei Hu, Itamar Willner, Li Niu
wiley   +1 more source