Results 201 to 210 of about 2,805,831 (274)

Stochastic epigenetic mutation profiles as biomarkers of clinical activity in juvenile idiopathic arthritis: a multi-omic machine learning approach for gene prioritization. [PDF]

Mol Med
Cavalca G, Vergani M, Cangelosi D, Consolaro A, Gattorno M, Ravelli A, Munro J, Novakovic B, Duncan A, Uva P, Fiorito G.   +10 more
europepmc   +1 more source

Phen2Gene: rapid phenotype-driven gene prioritization for rare diseases. [PDF]

NAR Genom Bioinform, 2020
Zhao M, Havrilla JM, Fang L, Chen Y, Peng J, Liu C, Wu C, Sarmady M, Botas P, Isla J, Lyon GJ, Weng C, Wang K.   +12 more
europepmc   +1 more source

Drought Stress Mediated Changes in Food Crops: Mechanisms and Remediation Strategies

Advanced Science, EarlyView.
This work presents a multi‐scale framework for flavonoid‐mediated drought tolerance in staple food crops, integrating ROS redox regulation, antioxidant defense, rhizosphere microbial interactions, and sustainable agronomic practices. This interdisciplinary model provides core insights to develop climate‐resilient cropping systems and enhance global ...
Xiaoyi Duan, Litao Wang, Tuuli‐Marjaana Koski, Lizhe An, Thomas Efferth, Yujie Fu   +5 more
wiley   +1 more source

A Biofabricated Human Acinus‐on‐a‐Chip Unveils Mechanotransductive Drivers of Ventilator‐Induced Lung Injury via Decoupling Volutrauma and Barotrauma

Advanced Science, EarlyView.
This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu, Liansheng Liu, Zengyong Hu, Shuxian Fang, Ruohan Ren, Sidi Liu, Meng Zhao, Zhiting Luo, Ziyue Zhang, Wenlong Shao, Qian Liu   +10 more
wiley   +1 more source

Identifying key genes in COPD risk via multiple population data integration and gene prioritization. [PDF]

PLoS One
Zainab A, Anzawa H, Kinoshita K.
europepmc   +1 more source

Fzd7 Restrains Pink1‐Dependent Mitophagy in Suture Stem Cells to Maintain Cranial Suture Patency

Advanced Science, EarlyView.
How suture stem cells fail to preserve cranial suture patency remains incompletely understood. Integrated single‐cell and high‐resolution spatial transcriptomic analyses identify reduced Fzd7 expression in Prrx1+ suture stem cells as an early feature of craniosynostosis.
Xinyan Chen, Zong Chen, Chenzhi Lai, Yingying Yue, Tian He, Hao Gong, Jing Shi, Xiaoshuang Guo, Yu Wang, Guodong Song, Xiaolei Jin   +10 more
wiley   +1 more source

Mapping Molecular Pathways of Multiple Sclerosis: A Gene Prioritization and Network Analysis of White Matter Pathology Transcriptomics. [PDF]

Ann Neurol
Abbadessa G, Nagano A, Hametner S, Howell O, Owen D, Papadaki A, Srivastava P, Bonavita S, Magliozzi R, Reynolds R, Rizig M, Nicholas R.   +11 more
europepmc   +1 more source

A gene prioritization method based on a swine multi-omics knowledgebase and a deep learning model. [PDF]

Commun Biol, 2020
Fu Y, Xu J, Tang Z, Wang L, Yin D, Fan Y, Zhang D, Deng F, Zhang Y, Zhang H, Wang H, Xing W, Yin L, Zhu S, Zhu M, Yu M, Li X, Liu X, Yuan X, Zhao S.   +19 more
europepmc   +1 more source

Gene prioritization by data integration [PDF]

, 2012
Jiang, Li, Janss, Luc; id_orcid 0000-0001-9804-1529, Høj-Edwards, Stefan McKinnon, Skarman, Axel, Thomsen, Bo; id_orcid 0000-0001-9622-0929, Sørensen, Peter   +5 more
openaire   +1 more source

Selective Modulation of OTUB1 Noncanonical Function via a bioPhosTAC Strategy

Advanced Science, EarlyView.
This work positions the versatile performance of the peptide‐based bioPhosTAC platform for dissecting phosphorylation‐dependent biology and expanding the scope of induced‐proximity technologies. We demonstrated that selective manipulation of a tyrosine phosphorylation site is sufficient to propagate coordinated cellular consequences.
Seung Un Seo, Seon Min Woo, Minhyeong Choi, Soeun Rhee, Simmyung Yook, Donghyuk Shin, Kwang‐Su Park, Taeg Kyu Kwon   +7 more
wiley   +1 more source