Results 181 to 190 of about 271,468 (359)

New chromosome abnormalities and lack of BCL‐6 gene rearrangements in Argentinean diffuse large B‐cell lymphomas [PDF]

, 2006
Roxana Cerretini, María Fernanda Noriega, Marina Narbaitz, Irma Slavutsky   +3 more
openalex   +1 more source

Data from Characterization of Rearrangements Involving the <i>ALK</i> Gene Reveals a Novel Truncated Form Associated with Tumor Aggressiveness in Neuroblastoma

, 2023
Alex Cazes, Caroline Louis‐Brennetot, Pierre Mazot, Florent Dingli, Bérangère Lombard, Valentina Boeva, Romain Daveau, Julie Cappo, Valérie Combaret, Gudrun Schleiermacher, Stéphanie Jouannet, Sandrine Ferrand, Gaëlle Pierron, Emmanuel Barillot, Damarys Loew, Marc Vigny, Olivier Delattre, Isabelle Janoueix‐Lerosey   +17 more
openalex   +1 more source

Hippocampal Chandelier Cells Modulate Seizure Susceptibility and Severity

Advanced Science, EarlyView.
The axon initial segment (AIS), crucial for action potential initiation, serves as a prime locus for controlling network activity. Chandelier Cells (ChCs), evolved in the mammals, intricately target AISs, acting as gatekeepers for neuronal firing. Diminishing ChC input makes animals more prone to developing seizures, whereas fortifying this connection ...
Yang Li, Jifeng Tian, Jiafan Wei, Qianyun Wang, Jiaxu Ge, Jianguang Ni, Jiangteng Lu, Yilin Tai   +7 more
wiley   +1 more source

Positive Selection Drives Mitochondrial Gene Rearrangement in Sternorrhyncha (Insecta: Hemiptera). [PDF]

Ecol Evol
Zhao TY, Wei JF, Li CF, Chen YN, Lü L, Wang F.   +5 more
europepmc   +1 more source

Recurrent Rearrangements in Synaptic and Neurodevelopmental Genes and Shared Biologic Pathways in Schizophrenia, Autism, and Mental Retardation

, 2009
Audrey Guilmatre, Christèle Dubourg, A.L. Mosca, Solenn Legallic, Alice Goldenberg, Valérie Drouin‐Garraud, Valérie Layet, Antoine Rosier, Sylvain Briault, Frédérique Bonnet‐Brilhault, Frédéric Laumonnier, Sylvie Odent, G. Le Vacon, Géraldine Joly‐Hélas, Véronique David, Claude Bendavid, Jean‐Michel Pinoit, Céline Henry, Caterina Impallomeni, Eva Germanò, Gaetano Tortorella, Gabriella Di Rosa, Catherine Barthélémy, Christian Andrés, Laurence Faivre, Thierry Frébourg, Pascale Saugier-Véber, Dominique Campion   +27 more
openalex   +2 more sources

Hepatitis E Virus ORF1 Polyprotein Harbors a Pocket‐Like Cavity That Is Vital for Virus Replication and Represents a Novel Antiviral Target

Advanced Science, EarlyView.
Within the hepatitis E virus (HEV) ORF1 polyprotein, the X domain interacts with viral RNA‐dependent RNA polymerase (RdRp), forming a functional “pocket‐like” cavity (PC) that is crucial for viral replication. Structure‐based screening, surface plasmon resonance (SPR) assays, and HEV model validation collectively identify saikosaponin D and ...
Xiaohui Ding, Dou Zeng, Dan Liu, Yingying Bian, Bin Li, Zheng Li, Qiudi Li, Shiquan Liang, Yunlong Si, Qili Yao, Yibo Ding, Jiahui Zhu, Xiangyang Li, Kuiyang Zheng, Hongbo Guo, Wenshi Wang   +15 more
wiley   +1 more source

The Complete Mitochondrial Genome of the Stingless Bee <i>Meliplebeia beccarii</i> (Hymenoptera: Apidae: Meliponini) and Insights into Unusual Gene Rearrangement. [PDF]

Int J Mol Sci
Wang SJ, Wu J, Wubie AJ, Wang CY.
europepmc   +1 more source

Primary Lung Adenocarcinoma With ALK Gene Rearrangement Mostly Occupied by the Signet-Ring Cell Carcinoma Component: A Case Report. [PDF]

Cureus, 2023
Okimura A, Hirano H, Ito Y, Kajiwara N, Nakatsugawa M.   +4 more
europepmc   +1 more source

Predicting Immunotherapy Outcomes in NSCLC Using RNA and Pathology from Multicenter Clinical Trials

Advanced Science, EarlyView.
LIRA, a machine learning‐based model, is developed using transcriptomic data from 891 NSCLC patients in the OAK and POPLAR cohorts. Its predictive performance is validated in multiple external cohorts. Patients stratified by LIRA‐score exhibit distinct clinical characteristics and tumor microenvironment profiles.
Zhaojun Wang, Yiran Fang, Xiatong Huang, Guichuang Ma, Qianqian Mao, Xiansheng Lu, Guangda Rong, Yunfang Yu, Yuanyuan Wang, Zhenhua Huang, Huiying Sun, Jiani Wu, Wenchao Gu, Na Huang, Jianhua Wu, Rui Zhou, Xiaoxiang Rong, Siting Zheng, Shaowei Li, Gaofeng Wang, Ling Wang, Wenjun Qiu, Luyang Jiang, Peng Luo, Yonggang Liu, Jianping Bin, Yulin Liao, Min Shi, Zuqiang Wu, Jiguang Wang, Wangjun Liao, Gang Chen, Dongqiang Zeng   +32 more
wiley   +1 more source

C082 | T-CELL RECEPTOR-VΒ REPERTOIRE FLOW CYTOMETRY ANALYSIS SHOWED ABSOLUTE CONCORDANCE WITH MOLECULAR ANALYSIS OF TCR GENE REARRANGEMENT IN THE DIAGNOSIS OF T-CELL LYMPHOPROLIFERATIVE DISORDER: OBSERVATIONAL STUDY FROM A SINGLE CENTER EXPERIENCE.

Haematologica
Background: Clonality assessment is critical to differentiate between reactive and pathological T- cell lymphocytosis, and it usually relies on molecular analysis of T-Cell Receptor (TCR) gene rearrangement, which is considered the gold standard assay ...
M. Antonacci, J. Micozzi, A. Costa, A. Laganà, M.L. Milani, S. Intoppa, V. Bellomarino, M.G. Nardacci, M. Biglietto, S. Imperatore, M.L. Bisegna, M. Martelli, I. Della Starza, M.S. De Propris   +13 more
doaj