Results 311 to 320 of about 271,468 (359)
Advanced Science, EarlyView.The advent of aptamers has highlighted their potential as alternatives to antibodies, overcoming limitations of structural instability and production cost. However, conventional approaches such as SELEX remain slow and labor‐intensive. This review examines recent advances in aptamer engineering, emphasizing in vitro and AI‐driven in silico strategies ...
John V. L. Nguyen +5 more
wiley +1 more source
Advanced Science, EarlyView.Activated neutrophils release extracellular traps (NETs) that promote tumor metastasis. FTP‐NPs are develpoed, a peptidic nanomaterial that binds NE on neutrophil membranes, forming NE‐fibril clusters that deactivate NE and prevent NETs formation. This strategy reduces metastasis and enhances the anti‐tumor immune response by targeting NE subcellular ...
Yichi Chen +13 more
wiley +1 more source
Thermally Gated Dual‐Cascade Nanozyme for Enhanced Mild‐Temperature Photothermal Therapy
Advanced Science, EarlyView.A thermo‐responsive cascade nanozyme (Ru‐GOx‐PNN) synergistically enhances mild photothermal therapy by dual suppression of HSP70 through ROS‐induced lipid peroxidation and ATP depletion. This intelligent system effectively overcomes thermotolerance and amplifies apoptosis, offering a safe and precise strategy for tumor treatment.
Shuyu Wang +7 more
wiley +1 more source
Reticular Chemistry: A Versatile Platform for Engineering Heterogenous Biocatalysts
Advanced Science, EarlyView.Rational design of reticular‐based heterogeneous biocatalysts enables significant enhancement in enzyme activity recovery and even achieves catalytic performance beyond native enzymes. Abstract Reticular materials, including metal‐organic frameworks (MOFs), covalent organic frameworks (COFs), and hydrogen‐bonded organic frameworks (HOFs), have emerged ...
Si Liu +6 more
wiley +1 more source
Cross‐Platform Biosensing of Immune Receptors Using Peptide‐Functionalized Graphene
Advanced Science, EarlyView.A peptide‐functionalized graphene biosensor enables sensitive and selective detection of living immune cells. Targeting Formyl‐Peptide Receptor 2 (FPR2), the assay is demonstrated on model cells and primary human neutrophils. The same assay is applied to two complementary platforms: graphene‐enhanced surface plasmon resonance for optical benchmarking ...
Ahmar Hasnain +5 more
wiley +1 more source
Advanced Intelligent Systems, EarlyView.Here, we present RanBALL, an ensemble random projection‐based model for accurate and cost‐effective identification of B‐cell acute lymphoblastic leukemia subtypes is presented. By preserving patient‐to‐patient distance after dimension reduction by random projection and ensemble learning, RanBALL can facilitate the discovery of B‐ALL subtype‐specific ...
Lusheng Li +6 more
wiley +1 more source
[A consistency comparison between next-generation sequencing and the FISH method for gene rearrangement detection in B-cell lymphomas]. [PDF]
Zhonghua Xue Ye Xue Za ZhiYan Z +14 more
europepmc +1 more source
Pangenomes as a framework for adaptive radiation, speciation, and adaptation
American Journal of Botany, EarlyView.Abstract Understanding the genomic basis of diversification is a central goal in evolutionary biology. In recent years, the development and use of pangenomes, a genomic representation of multiple individuals within a lineage (a set of related populations, subspecies, ecotypes, or species), has enabled researchers to differentiate between DNA sequences ...
Nicolò Tellini +5 more
wiley +1 more source
T-cell receptor gamma gene rearrangement analysis of classic Hodgkin lymphoma using a BIOMED-2 assay: a paraffin-embedded tissue analysis of one hundred cases. [PDF]
J Clin Exp HematopTakata K +4 more
europepmc +1 more source