Results 191 to 200 of about 1,853,089 (266)

Versatile CRISPR-Cas Tools for Gene Regulation in Zebrafish via an Enhanced Q Binary System. [PDF]

Adv Sci (Weinh)
Shi M, Ge W, Li C, Liu B, Deng X, Liu C, Zheng M, Zhang P, Li L, Guo Y, Han Y, Yang Y, Yu YV, Jin YN.   +13 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Allelic value in gene regulation-implications for gene editing. [PDF]

Ann Bot
Moin M, Rai M, Tyagi W.
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Identification of cis-regulatory elements provides insights into tissue-specific gene regulation in the sheep genome. [PDF]

Nat Commun
Xie S, Davenport KM, Salavati M, Caulton A, Clark EL, Archibald AL, Clarke SM, Brauning R, Massa AT, Mousel MR, White SN, Worley KC, Murdoch GK, Becker G, Stegmiller MR, Khilji SF, Shira KA, Olagunju TA, Hadfield T, McKay SD, Rosen BD, Cockett NE, Smith TPL, Murdoch BM.   +23 more
europepmc   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Illuminating biomolecular assemblies in gene regulation. [PDF]

Biophys Rev
Dixon E, Stanczyk K, Markaki Y.
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Gene Regulation in Comorbid Migraine and Myogenic Temporomandibular Disorder Pain. [PDF]

Genes (Basel)
Tao R, Liu S, Maltezos H, Tao F.
europepmc   +1 more source