Results 71 to 80 of about 6,256,288 (301)

Dualistic role of ZEB1 and ZEB2 in tumor progression

Biology Direct
It is generally accepted that ZEB1 and ZEB2 act as master regulators of the epithelial-mesenchymal transition, which arguably is the key mechanism of metastasis.
Sergey E. Parfenyev, Alexandra A. Daks, Oleg Y. Shuvalov, Olga A. Fedorova, Nikolay B. Pestov, Tatyana V. Korneenko, Nickolai A. Barlev   +6 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Down-regulation of CBP80 gene expression as a strategy to engineer a drought-tolerant potato [PDF]

, 2012
Developing new strategies for crop plants to respond to drought is crucial for their innovative breeding. The down-regulation of nuclear cap-binding proteins in Arabidopsis renders plants drought tolerant.
Strzelczyk-Zyta, Danuta, Szweykowska-Kulinska, Zofia, Bielewicz, Dawid, Dolata, Jakub, Piontek, Paulina, Wyrzykowska, Anna, Krusiewicz, Dominika, Jarmołowski, Artur, Krzeslowska, Magdalena, Hennig, Jacek, Pieczynski, Marcin, Konopka-Postupolska, Dorota, Marczewski, Waldemar   +12 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Acute phase induction of the human C-reactive protein gene in transgenic mice

, 1987
Regulation of human C-reactive protein ...
ARCONE, Rosaria
core  

miRNA-Mediated KHSRP Silencing Rewires Distinct Post-transcriptional Programs during TGF-β-Induced Epithelial-to-Mesenchymal Transition

Cell Reports, 2016
Epithelial-to-mesenchymal transition (EMT) confers several traits to cancer cells that are required for malignant progression. Here, we report that miR-27b-3p-mediated silencing of the single-strand RNA binding protein KHSRP is required for transforming ...
Margherita Puppo, Gabriele Bucci, Martina Rossi, Matteo Giovarelli, Domenico Bordo, Arfa Moshiri, Franco Gorlero, Roberto Gherzi, Paola Briata   +8 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Identification of hepatocyte nuclear proteins wich interact with the human C-reactive promoter

, 1989
Regulation of Human C-reactive protein gene ...
Ciliberto G, Ganter U, Majello B, Arpaia G, Toniatti C., ARCONE, Rosaria   +5 more
core  

Antiangiogenic gene therapy

, 2000
A number of potent endogenous inhibitors targeting the tumor vasculature have recently been identified in tumor-bearing animals. Some of these angiogenesis inhibitors, including angiostatin, endostatin, and serpin antithrombin, seem to act specifically ...
Cao, Y,
core   +1 more source

A lncRNA-SWI/SNF complex crosstalk controls transcriptional activation at specific promoter regions

Nature Communications, 2020
SWI/SNF complexes regulate chromatin architecture and gene expression. Here the authors report the RNA interactome of SMARCB1-containing SWI/SNF complexes, showing the function of SMARCB1-interacting long noncoding RNA SWINGN in transcriptional ...
Elena Grossi, Ivan Raimondi, Enrique Goñi, Jovanna González, Francesco P. Marchese, Vicente Chapaprieta, José I. Martín-Subero, Shuling Guo, Maite Huarte   +8 more
doaj   +1 more source