Results 171 to 180 of about 6,728,627 (290)

Probing transcription factor subsets in gene regulatory networks. [PDF]

Algorithms Mol Biol
Geis L, Hecker D, Hoefer M, Meyer U, Schulz MH.   +4 more
europepmc   +1 more source

On gene regulatory networks and data fitting. [PDF]

, 2016
Living organisms can be viewed as complex biological machines. In order to function, they must regulate their internal mechanism to do the right thing, at the right time, and in the right amount. Part of this regulation is encoded in gene regulatory networks.
openaire   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

CroCoNet: a framework for the quantitative comparison of gene regulatory networks across species. [PDF]

Genome Biol
Térmeg A, Storozhuk V, Kliesmete Z, Edenhofer FC, Geuder J, Dietl T, Vieth B, Janssen P, Richter D, Bonev B, Hellmann I.   +10 more
europepmc   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Integrating transposable elements into blood gene regulatory networks reveals connectivity loss for schizophrenia genes. [PDF]

J Clin Invest
Reyes-Gopar H, Bendall ML, Duarte RR, Powell TR, Nixon DF.   +4 more
europepmc   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Constructing cell-type-specific gene regulatory networks from cell-cell communication and a global gene regulatory network. [PDF]

Brief Bioinform
Xie Y, Fu B, Zhong L, Wu L, Li H, Chang X, Liu X.   +6 more
europepmc   +1 more source

Characterization of the key membrane protein cytochrome Cyc2 from Ghiorsea bivora

FEBS Open Bio, EarlyView.
This study reports the first detailed biochemical analysis of Cyc2TAG1_1, a cytochrome protein involved in microbial iron oxidation. We produced and purified this enzyme in E. coli, then measured its iron‐oxidizing efficiency, and characterized its electrical and structural properties.
Josiane Azizi, Alain Dolla, Frauke Baymann, Celine Rommevaux, Latifa Elantak, Helene Gaussier, Matthieu Nouailler   +6 more
wiley   +1 more source

Conserved and divergent gene regulatory networks for crop drought resistance. [PDF]

Nat Commun
Deng X, Shi L, Wang Y, Qiao H, Wang X, Ma J, Zhang Y, Zha Y, Hu X.   +8 more
europepmc   +1 more source