Results 171 to 180 of about 946,920 (339)
The gene regulatory networks controlled by estrogens.Mol
, 2011 a b s t r a c t Estrogen signaling occurs widely among vertebrates and in some invertebrates. Estrogen action is mediated by estrogen receptors through the regulation of target gene expression.
Karin Dahlman-Wright, Hui Gao
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Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Reverse Engineering of A. thaliana Gene Regulatory Networks
, 2017 In this paper, biological background of cells' regulatory mechanisms as well as gene regulatory networks are described. The models applied to infer gene regulatory networks such as Boolean networks, dynamic Bayesian networks , graphical Gaussian models ...
Ristevski, Blagoj
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Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Stochastic-Kinetic modeling of synthetic gene regulatory networks
, 2009 University of Minnesota Ph.D. dissertation. July 2009. Major: Chemical engineering. Advisor: Yiannis Kaznessis. 1 computer file (PDF); vii, 144 pages. Ill.
Tomshine, Jonathan Robert
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Computational methods for the Inference of Gene Regulatory Networks
, 2020 Summary In the last 10 years, Inference of Gene Regulatory Networks from Microarray data has become an important research area in Bioinformatics. Several algorithms have been proposed and Regulatory networks have been inferred with good accuracy for ...
Accaamma V, † † Faculty, Seema More
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
, 2009 textIt has been suggested that organismal complexity correlates with the complexity of gene regulation. Transcriptional control of gene expression is mediated by binding of regulatory proteins to cis-acting sequences on the genome. Hence, it is crucial
Bhinge, Akshay Anant
core +1 more source