Results 191 to 200 of about 946,920 (339)

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Probing transcription factor subsets in gene regulatory networks. [PDF]

Algorithms Mol Biol
Geis L, Hecker D, Hoefer M, Meyer U, Schulz MH.   +4 more
europepmc   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Conserved and divergent gene regulatory networks for crop drought resistance. [PDF]

Nat Commun
Deng X, Shi L, Wang Y, Qiao H, Wang X, Ma J, Zhang Y, Zha Y, Hu X.   +8 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Inferring gene-regulatory networks using epigenomic priors. [PDF]

iScience
Bartlett TE, Li M, Song C, Gao Y, Huang Q.   +4 more
europepmc   +1 more source

Response to Comment on "Gene Regulatory Networks and the Evolution of Animal Body Plans"

, 2006
Contrary to Coyne's assertions, our paper did not advocate a macromutational innovation of phyla but considered the consequences of the introduction of developmental constraints for the evolution of gene regulatory networks based on recent empirical ...
Erwin, Douglas H., Davidson, Eric H.
core  

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Inferring cell-specific gene regulatory networks based on causal graph embedding. [PDF]

Cell Rep Methods
Li G, Qiao R, Xu Y, Jiao F, Li P, Chen L.   +5 more
europepmc   +1 more source

A Bayesian framework for the inference of gene regulatory networks from time and pseudo‐time series data

Bioinform., 2018
M. Sánchez-Castillo, D. Blanco, I. M. Tienda-Luna, M. Perez, Yufei Huang   +4 more
semanticscholar   +1 more source