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Natural selection on gene expression
Trends in Genetics, 2006Changes in genetic regulation contribute to adaptations in natural populations and influence susceptibility to human diseases. Despite their potential phenotypic importance, the selective pressures acting on regulatory processes in general and gene expression levels in particular are largely unknown.
Yoav, Gilad +2 more
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Natural Selection and the Complexity of the Gene
Nature, 1969Conflict between the idea of natural selection and the idea of the uniqueness of the gene does not seem too near to a solution yet.
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Gene selection for Brain Cancer Classification
2006 International Conference of the IEEE Engineering in Medicine and Biology Society, 2006With the introduction of microarray, cancer classification, diagnosis and prediction are made more accurate and effective. However, the final outcome of the data analyses very much depend on the huge number of genes with relatively small number of samples present in each experiment.
Yuk Yee Leung +3 more
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Selecting maximally informative genes
Computers & Chemical Engineering, 2005Microarray experiments are emerging as one of the main driving forces in modern biology. By allowing the simultaneous monitoring of the expression of the entire genome for a given organism, array experiments provide tremendous insight into the fundamental biological processes that translate genetic information.
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Selection of Candidate Genes in Hypertension
2005Essential hypertension is a common disease with multifactorial etiology affecting up to 10 million individuals in the United Kingdom alone. Current knowledge of the genetic contribution to this trait is restricted to a number of rare variants that produce hypertensive phenotypes in a Mendelian fashion and to genes highlighted by work on blood pressure ...
Charles A, Mein +2 more
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Selective gene mutation in MEL cells
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1992MEL cells, undergoing erythroid differentiation and parasynchronized by dimethyl sulfoxide (DMSO) induction, were irradiated with a 3-s pulse of UV light at sublethal dose. A large number of clones deficient in different gene functions are found in the progeny of the treated cells, if the pulse irradiation is performed 18-24 h from the start of DMSO ...
FORESTI, MAGDA +2 more
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Statistical Selection of Maintenance Genes for Normalization of Gene Expressions
Statistical Applications in Genetics and Molecular Biology, 2006Maintenance genes can be used for normalization in the comparison of gene expressions. Even though the absolute expression levels of maintenance genes may vary considerably among different tissues or cells, a set of maintenance genes may provide suitable normalization if their expression levels are relatively constant in the specific tissues or cells ...
Yifan, Huang +3 more
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Gene Expression and Selection of Major Genes
2016Genes are examined in detail that proved important for establishing the laws of inheritance, domestication and adaptation of crops to new environments, selection of colour and shape, the green revolution and for herbicide tolerance. They are all simply inherited genes with phenotypes that were easy to recognize and select by farmers and plant breeders.
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Selecting Few Genes for Microarray Gene Expression Classification
2010Due to the high number of gene expressions contained on microarray data, feature extraction techniques are usually applied before inducing classifiers. A common criterion to decide on the number of selected genes is minimizing the classifier error. However, considering the risk of overfitting due to the small sample size, and the fact that the number ...
Carlos J. Alonso-González +3 more
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The gene as a unit of selection
1992Abstract Well-reasoned treatments of Darwinism for wide audiences (e.g. Sober 1984; Lloyd 1988; Brandon 1990) have recently had the benefit of Dawkins’ (1976, 1982b) and Hull’s (1988) concepts of replicators and interactors. The concepts are general in scope, but replicators usually mean genes, and interactors the individual organisms ...
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