Results 81 to 90 of about 2,179,747 (304)

Metabolic Pathways Enhancement Confers Poor Prognosis in p53 Exon Mutant Hepatocellular Carcinoma. [PDF]

, 2020
RNA-Sequencing (RNA-Seq), the most commonly used sequencing application tool, is not only a method for measuring gene expression but also an excellent media to detect important structural variants such as single nucleotide variants (SNVs), insertion ...
Chen, Po-Ming, Chiang, Eugene, Li, Jian-Rong, Liu, Chun-Chi, Tang, Feng-Yao   +4 more
core  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Raman cell sorting for single-cell research

Frontiers in Bioengineering and Biotechnology
Cells constitute the fundamental units of living organisms. Investigating individual differences at the single-cell level facilitates an understanding of cell differentiation, development, gene expression, and cellular characteristics, unveiling the ...
Xusheng Tang, Xusheng Tang, Qingyi Wu, Qingyi Wu, Lindong Shang, Lindong Shang, Kunxiang Liu, Kunxiang Liu, Yan Ge, Yan Ge, Peng Liang, Peng Liang, Peng Liang, Bei Li, Bei Li, Bei Li   +15 more
doaj   +1 more source

The Technology and Innovation Unit of the National Institute of Health: A sequencing and bioinformatics core facility specializing in public health genomics [PDF]

, 2019
The National Institute of Health (INSA) has a long tradition in investigating the molecular etiology of genetic and complex diseases. These activities greatly benefit from centralized sequencing services provided by the Technology and Innovation Unit ...
Ataíde Sampaio, Daniel, Barreiro, Paula, Carpinteiro, Dina, Duarte, Sílvia, Isidro, Joana, Machado, Miguel, Mendonça, Joana, Silva, Catarina, Vieira, Luís   +8 more
core   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Sequencing technology in sarcopenia: current research progress and future trends

Frontiers in Molecular Biosciences
BackgroundMuscle is an important tissue of the human body. Muscle atrophy is common in people of all ages, which will lead to human weakness and decline of motor function, which is one of the important causes of disability. The common methods of genomics
Yuxia Yang, Xiangji Meng, Xiaomei Dai, Jian Zhang, Jihang Dai, Jingcheng Wang, Wenyong Fei   +6 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

A new RT-PCR assay for the revealing of Newcastle disease viruses by designing a pair of universal primers [PDF]

Iraqi Journal of Veterinary Sciences
Newcastle disease viruses (NDVs) possess a single-stranded, non-segmented RNA and are classified into different strains based on their level of pathogenicity.
Firas T. Al-Mubarak, Afnan G. Yaqoub, Manar M. Alnassar   +2 more
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Transcriptome analysis of cortical tissue reveals shared sets of downregulated genes in autism and schizophrenia. [PDF]

, 2016
Autism (AUT), schizophrenia (SCZ) and bipolar disorder (BPD) are three highly heritable neuropsychiatric conditions. Clinical similarities and genetic overlap between the three disorders have been reported; however, the causes and the downstream effects ...
Arking, DE, Ellis, SE, Panitch, R, West, AB   +3 more
core   +1 more source