Results 91 to 100 of about 631,661 (355)
The classification of melanocytic gene signatures
Pigment Cell & Melanoma ResearchAbstractGene expression profiling technologies have revolutionized cell biology, enabling researchers to identify gene signatures linked to various biological attributes of melanomas, such as pigmentation status, differentiation state, proliferative versus invasive capacity, and disease progression.
Min Hu +3 more
openaire +2 more sources
Gene expression signature of obesity in monozygotic twins [PDF]
Physiological Measurement, 2018 Observational studies suggest that obesity might have a Mendelian origin, but it is not clear if gene expression patterns observed in obese subjects are secondary to genetic traits or not.Here we test a transcriptomic signature of obesity previously identified by our group on a large cohort of twin subjects (TwinsUK).The results show that the signature
Font-Clos, Francesc +2 more
openaire +5 more sources
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Characteristics and Validation Techniques for PCA-Based Gene-Expression Signatures
International Journal of Genomics, 2017 Background. Many gene-expression signatures exist for describing the biological state of profiled tumors. Principal Component Analysis (PCA) can be used to summarize a gene signature into a single score.
Anders E. Berglund +2 more
doaj +1 more source
Peripheral blood gene expression as a novel genomic biomarker in complicated sarcoidosis. [PDF]
PLoS ONE, 2012 Sarcoidosis, a systemic granulomatous syndrome invariably affecting the lung, typically spontaneously remits but in ~20% of cases progresses with severe lung dysfunction or cardiac and neurologic involvement (complicated sarcoidosis).
Tong Zhou +10 more
doaj +1 more source
Establishing cost-effectiveness of genetic targeting of cancer therapies\ud [PDF]
, 2008 The clinical benefit of a new genomic instrument, the 70-gene signature\ud for breast cancer patients, is being evaluated in a randomised clinical\ud trial.
Harten, W.H. van +3 more
core +2 more sources
Prognostic stromal gene signatures in breast cancer [PDF]
Breast Cancer Research, 2015 Abstract Introduction Global gene expression analysis of tumor samples has been a valuable tool to subgroup tumors and has the potential to be of prognostic and predictive value. However, tumors are heterogeneous, and homogenates will consist of several different cell types.
Winslow, Sofia +3 more
openaire +5 more sources
FEBS Letters, EarlyView.Phototrophs evolved light‐harvesting systems adapted for efficient photon capture in habitats enriched in far‐red radiation. A subset of eukaryotic pigment‐binding proteins can absorb far‐red photons via low‐energy chlorophyll states known as red forms.
Antonello Amelii +8 more
wiley +1 more source
A 16-gene signature predicting prognosis of patients with oral tongue squamous cell carcinoma [PDF]
PeerJ, 2017 Background Oral tongue squamous cell carcinoma (OTSCC) is the most common subtype of oral cancer. A predictive gene signature is necessary for prognosis of OTSCC.
Zeting Qiu +6 more
doaj +2 more sources
Establishing cost-effectiveness of genetic targeting of cancer therapies [PDF]
, 2011 The clinical benefit of a new genomic instrument, the 70-gene signature for breast cancer patients, is being evaluated in a randomised clinical trial. The early, controlled implementation process is supported by a Constructive Technology Assessment to ...
Harten, W.H. van +3 more
core +1 more source