Results 111 to 120 of about 3,125,604 (306)

Computational prediction of diagnostic biomarker candidates and prognostic gene signature from DNA replication-related genes in breast cancer

Discover Oncology
Background Given the role of DNA replication in tumorigenesis, identifying diagnostic and prognostic biomarkers of this process using machine learning approaches may reveal new therapeutic targets and improve prognostic assessment in breast cancer ...
Ceren Sucularli
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Transcriptional Blood Signatures Distinguish Pulmonary Tuberculosis, Pulmonary Sarcoidosis, Pneumonias and Lung Cancers [PDF]

, 2013
Rationale New approaches to define factors underlying the immunopathogenesis of pulmonary diseases including sarcoidosis and tuberculosis are needed to develop new treatments and biomarkers. Comparing the blood transcriptional response of tuberculosis
Lipman, M, Derek Blankenship, Katalin A Wilkinson, Christine M Graham, Xu, Zhaohui, Vancheeswaran, Rama, Matthew P. R. Berry (130010), Anne O’Garra (130055), Dominique, Valeyre, Beynon, H, Banchereau, J, Rama Vancheeswaran, Guy Gorochov, Virginia Pascual, Anne O'Garra, Ling-pei Ho, Phillip Vanhems, Damien Chaussabel (26369), Pascual, V, Phillip Vanhems (441320), Xu, Z, Yvonne Kendrick (441315), Kendrick, Yvonne, Rozakeas, F, Chloe I. Bloom (130006), Lipman, Marc, Huw Beynon (441321), Vanhems, Phillip, Fotini Rozakeas, Wickremasinghe, Melissa, Christine M. Graham (130008), Miyara, M, Jacques Banchereau, Wickremasinghe, M, Marc Lipman, Matthew P. R. Berry, Diane Bouvry (441317), Yuanyuan Wang, Huw Beynon, Ferry, T, Berry, MP, Blankenship, D, Derek Blankenship (173502), Wilkinson, Robert J, Gilles Devouassoux (441316), Dominique, V, Ferry, Tristan, Paul S. Redford (441314), Robert J. Wilkinson, Berry, MPR, Matthew P R Berry, Melissa Wickremasinghe, Jacques Banchereau (4187), Wilkinson, Katalin A, Valeyre Dominique, Redford, Paul S, Zhaohui Xu, Saadatian, Mitra, Gilles Devouassoux, Berry, Matthew P R, Wang, Y, O\u27Garra, Anne, Yuanyuan Wang (20181), Rama Vancheeswaran (441322), Blankenship, Derek, Vancheeswaran, R, Katalin A. Wilkinson, Saadatian, M, Mitra Saadatian, Paul S. Redford, O'Garra, A, Chaussabel, Damien, Diane Bouvry, Devouassoux, G, Melissa Wickremasinghe (235318), Ho, LP, Robert J Wilkinson, Ho, Ling-Pei, Mitra Saadatian (441319), Guy Gorochov (89307), Wilkinson, KA, Pascual, Virginia, Rozakeas, Fotini, Katalin A. Wilkinson (130012), Robert J. Wilkinson (130050), Zhaohui Xu (130026), Damien Chaussabel, Gorochov, Guy, Graham, CM, Beynon, Huw, Valeyre, D, Tristan Ferry, Tristan Ferry (412308), Redford, PS, Bloom, Chloe I, Virginia Pascual (130037), Bouvry, D, Chaussabel, D, Chloe I. Bloom, Marc Lipman (130043), Vanhems, P, Bloom, CI, Paul S Redford, Chloe I Bloom, Ling-pei Ho (5655859), Wang, Yuanyuan, Yvonne Kendrick, Anne O’Garra, Dominique Valeyre, Gorochov, G, Kendrick, Y, Makoto Miyara, Bouvry, Diane, Banchereau, Jacques, Miyara, Makoto, Valeyre Dominique (441318), Christine M. Graham, Devouassoux, Gilles, Ho, L-P, Wilkinson, RJ, Makoto Miyara (199979), Graham, Christine M, Fotini Rozakeas (130019)   +122 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Generalized Scheme For Fractal Based Digital Signature (GFDS). [PDF]

, 2007
This paper describes a new development in the cryptographic digital signature scheme based on Mandelbrot and Julia fractal sets. Recently it has been shown that it is possible to have digital signature scheme based on fractal due to the strong connection
Alia, Mohammad Ahmad, Samsudin, Azman
core   +1 more source

Prognostic implications of immune-related eight-gene signature in pediatric brain tumors [PDF]

Brazilian Journal of Medical and Biological Research
Genomic studies have provided insights into molecular subgroups and oncogenic drivers of pediatric brain tumors (PBT) that may lead to novel therapeutic strategies.
Yi Wang, Chuan Zhou, Huan Luo, Jing Cao, Chao Ma, Lulu Cheng, Yang Yang   +6 more
doaj   +2 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Genes and functions from breast cancer signatures

BMC Cancer, 2018
Background Breast cancer is a heterogeneous disease and personalized medicine is the hope for the improvement of the clinical outcome. Multi-gene signatures for breast cancer stratification have been extensively studied in the past decades and more than ...
Shujun Huang, Leigh Murphy, Wayne Xu
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

A novel gene-pair signature for relapse-free survival prediction in colon cancer

, 2018
Peng-fei Chen,1–3,* Fan Wang,1,2,* Zi-xiong Zhang,4,* Jia-yan Nie,1,2 Lan Liu,1,2 Jue-rong Feng,1,2 Rui Zhou,1,2 Hong-ling Wang,1,2 Jing Liu,1,2 Qiu Zhao1,2 1Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China;
Liu J, Chen P, Liu L, Feng J, Zhang Z, Zhao Q, Zhou R, Nie J, Wang F, Wang H   +9 more
core