Results 91 to 100 of about 3,125,604 (306)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Gene Signatures and Oncology Treatment Implications

Hematology/Oncology Clinics of North America
Gene expression signatures (GES) are a powerful tool in oncology used for classification, prognostication, and therapeutic response prediction of malignancies. In this article, we review the disease site guidelines by the National Comprehensive Cancer Network that use GES for treatment planning and clinical use.
Scarborough, Jessica, Weaver, Davis, Scott, Jacob   +2 more
openaire   +2 more sources

Adaptive feature thresholding for off-line signature verification [PDF]

, 2008
This paper introduces Adaptive Feature Thresholding (AFT) which is a novel method of person-dependent off-line signature verification. AFT enhances how a simple image feature of a signature is converted to a binary feature vector by significantly ...
Larkins, Robert L., Robert Larkins, Michael Mayo, Mayo, Michael   +3 more
core   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Identification of ferroptosis-related gene signature for tuberculosis diagnosis and therapy efficacy

iScience
Summary: Diagnosis of tuberculosis remains a challenge when microbiological tests are negative. Immune cell atlas of patients with tuberculosis and healthy controls were established by single-cell transcriptome.
Bingfen Yang, Fei Zhai, Zhimin Li, Xinjing Wang, Xianping Deng, Zhihong Cao, Yanhua Liu, Ruo Wang, Jing Jiang, Xiaoxing Cheng   +9 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Gene expression signature in transplantation tolerance

Clinica Chimica Acta, 2012
Human kidney transplantation tolerance exists, but the definition of true tolerance as defined by Billingham and colleagues suffers several key elements that cannot be demonstrated in humans. Indeed, human tolerance in transplantation is defined by different functional and clinical parameters, this is why in clinical transplantation we preferentially ...
Braza, Faouzi, Soulillou, Jean-Paul, Brouard, Sophie   +2 more
openaire   +4 more sources

Gene Signatures in CRC and Liver Metastasis [PDF]

, 2011
Colorectal cancer (CRC) is one of the most common causes of cancer-related death with a worldwide incidence of almost a million cases annually in both males and females. The accelerated decrease in CRC incidence rates from 1998 to 2006 largely reflects the advances in diagnosis and treatment that have enabled to detect and remove precancerous polyps ...
Fanale, Daniele, Corsini, Lidia, Rizzo, Sergio, Russo, Antonio   +3 more
openaire   +2 more sources

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Inter-species horizontal transfer resulting in core-genome and niche-adaptive variation within Helicobacter pylori [PDF]

, 2005
Background Horizontal gene transfer is central to evolution in most bacterial species. The detection of exchanged regions is often based upon analysis of compositional characteristics and their comparison to the organism as a whole.
Boonmee, P, Jarvis, SA, Boonmee, Prawit, Jarvis, Stephen A.; id_orcid, Peden, John F., Saunders, Nigel, Saunders, NJ, Peden, JF, Saunders, Nigel J., Jarvis, Stephen A., John F Peden, Boonmee Prawit, Prawit Boonmee, Stephen A Jarvis, Peden John F, Jarvis Stephen A, Saunders Nigel J, Nigel J Saunders   +17 more
core   +1 more source