Results 311 to 320 of about 12,185,719 (426)

A joint PCR-based gene-targeting method using electroporation in the pathogenic fungus Trichosporon asahii. [PDF]

AMB Express, 2022
Matsumoto Y, Nagamachi T, Yoshikawa A, Yamada T, Sugita T.   +4 more
europepmc   +1 more source

Targeting gene expression to specific cardiovascular cell types in transgenic mice. [PDF]

, 1993
John Hunter, Hong Zhu, K J Lee, S. Kubalak, Kenneth R. Chien   +4 more
openalex   +1 more source

Unraveling epigenetic heterogeneity across gastrointestinal adenocarcinomas through a standardized analytical framework

Molecular Oncology, Volume 19, Issue 4, Page 1117-1131, April 2025.
This study shows that patients with gastrointestinal adenocarcinomas can be stratified into six distinct subtypes based on genome‐scale DNA methylation profiling. This stratification, achieved using a robust analytical framework, aligns with established tumor characteristics and holds potential to support prognostication.
Rita Pinto, Hege Marie Vedeld, Guro Elisabeth Lind, Marine Jeanmougin   +3 more
wiley   +1 more source

CRISPR/Cas9 gene targeting plus nanopore DNA sequencing with the plasmid pBR322 in the classroom. [PDF]

J Microbiol Biol Educ
Wünschiers R, Leidenfrost RM, Holtorf H, Dittrich B, Dürr T, Braun J.   +5 more
europepmc   +1 more source

Increased Gene Targeting in Hyper-Recombinogenic LymphoBlastoid Cell Lines Leaves Unchanged DSB Processing by Homologous Recombination. [PDF]

Int J Mol Sci, 2022
Mladenov E, Paul-Konietzko K, Mladenova V, Stuschke M, Iliakis G.   +4 more
europepmc   +1 more source

In Situ Distinction between Steroid Receptor Binding and Transactivation at a Target Gene [PDF]

, 1991
Donald P. McDonnell, Zafar Nawaz, Bert W. O’Malley   +2 more
openalex   +1 more source

The CDK12–BRCA1 signaling axis mediates dinaciclib‐associated radiosensitivity through p53‐mediated cellular senescence

Molecular Oncology, Volume 19, Issue 4, Page 1265-1280, April 2025.
Dinaciclib blocks CDK12 activity, leading to downregulation of BRCA1, and probably other proteins involved in homologous recombination, promoting nonhomologous end joining. In this scenario, the presence of ionising radiation triggers a p53‐dependent senescent response that yields increased radiosensitivity. Pan‐cyclin‐dependent‐kinase (CDK) inhibitors
Natalia García Flores, Diego M. Fernández‐Aroca, Cristina Garnés‐García, Andrés Domínguez‐Calvo, Jaime Jiménez‐Suárez, Sebastià Sabater, Pablo Fernández‐Aroca, Ignacio Andrés, Francisco J. Cimas, Guillermo de Cárcer, Borja Belandia, Ignacio Palmero, Pablo Huertas, María José Ruiz‐Hidalgo, Ricardo Sánchez‐Prieto   +14 more
wiley   +1 more source

Comprehensive analysis of off-target and on-target effects resulting from liver-directed CRISPR-Cas9-mediated gene targeting with AAV vectors. [PDF]

Mol Ther Methods Clin Dev
Singh K, Fronza R, Evens H, Chuah MK, VandenDriessche T.   +4 more
europepmc   +1 more source

Autopolyploidization affects transcript patterns and gene targeting frequencies in Physcomitrella. [PDF]

Plant Cell Rep, 2022
Rempfer C, Wiedemann G, Schween G, Kerres KL, Lucht JM, Horres R, Decker EL, Reski R.   +7 more
europepmc   +1 more source

Visceral targets specify calcitonin gene-related peptide and substance P enrichment in trigeminal afferent projections [PDF]

, 1992
Kieran Horgan, Derek van der Kooy
openalex   +1 more source