Results 311 to 320 of about 1,756,365 (358)

Gene Targeting

1999
Since the publication of the first edition of Gene Targeting: A Practical Approach in 1993 there have been many advances in gene targeting and this new edition has been thoroughly updated and rewritten to include all the major new techniques. It provides not only tried-and-tested practical protocols but detailed guidance on their use and applications.
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Targetable Gene Delivery Vectors

2002
Adenoviral vectors, which have targeting ligands for tumor cells on the capsid, no natural tropism, and carry a therapeutic payload should be constructed soon and tested in pre-clinical models. Nevertheless, there are still important considerations for the design and therapeutic use of targetable vectors.
P L, Hallenbeck, S C, Stevenson
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Gene Targeting for Gene Therapy: Prospects

Molecular Genetics and Metabolism, 1999
Ideally, gene therapy involves the correction of genetic defects through the natural means of gene targeting. This therapy possesses a number of conceptual advantages. However, a major obstacle to successful gene therapy is the relative inefficiency of the targeting process in mammalian cells.
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Targeting Fumonisin Biosynthetic Genes

2016
The fungus Fusarium is an agricultural problem because it can cause disease on most crop plants and can contaminate crops with mycotoxins. There is considerable variation in the presence/absence and genomic location of gene clusters responsible for synthesis of mycotoxins and other secondary metabolites among species of Fusarium.
Robert H, Proctor, Martha M, Vaughan
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Conventional Murine Gene Targeting

2013
Murine gene knockout models engineered over the last two decades have continued to demonstrate their potential as invaluable tools in understanding the role of gene function in the context of normal human development and disease. The more recent elucidation of the human and mouse genomes through sequencing has opened up the capability to elucidate the ...
Albert G, Zimmermann, Yue, Sun
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Gene therapy targets XLP

Blood, 2013
Studying a murine model of X-linked lymphoproliferative syndrome (XLP), Rivat et al report in this issue of Blood that the immune function defects of the disorder are improved or corrected by lentiviral vector–mediated gene transfer of SH2D1A into autologous hematopoietic stem cells.[1][1] X-
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Target Genes: Bone Proteins

2005
http://www.elsevier.com/wps/find/bookdescription.cws_home/703914/description ...
Atkins, G., Findlay, D., Anderson, P., Morris, H.   +3 more
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Targeting Aflatoxin Biosynthetic Genes

2016
Chemical detoxification and physical destruction of aflatoxins in foods and feed commodities are mostly unattainable in a way that preserves the edibility of the food. Therefore, preventing mycotoxins in general and aflatoxins in particular from entering the food chain is a better approach.
Ali Y, Srour, Ahmad M, Fakhoury, Robert L, Brown   +2 more
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Targeting Ochratoxin Biosynthetic Genes

2016
The pathway of ochratoxin A (OTA) biosynthesis has not yet been completely elucidated. Essentially, two kind of genes have been demonstrated to be involved in the biosynthesis of OTA. One of them is the nrps gene encoding a non-ribosomal peptide synthetase (NRPS) which catalyzes the ligation between the isocoumarin group, constituting the polyketide ...
Gallo Antonia, Perrone Giancarlo
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Cancer epigenetics in clinical practice

Ca-A Cancer Journal for Clinicians, 2023
Veronica Davalos, Manel Esteller
exaly