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Radiotheranostics in oncology: Making precision medicine possible
Ca-A Cancer Journal for Clinicians, 2023Eric Aboagye
exaly
2011
The precise alteration of sequences by homologous recombination is an important strategy for gene therapies as well as investigating gene function and cellular DNA repair pathways. Inefficient delivery of template DNA to the nucleus using transfection or electroporation methods is one limitation of the frequency of homologous recombination in primary ...
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The precise alteration of sequences by homologous recombination is an important strategy for gene therapies as well as investigating gene function and cellular DNA repair pathways. Inefficient delivery of template DNA to the nucleus using transfection or electroporation methods is one limitation of the frequency of homologous recombination in primary ...
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Transcriptionally Targeted Gene Therapy
1996Gene therapy approaches for cancer treatment have moved from the laboratory to evaluation in the clinic (Culver and Blaese 1994; Nabel et al. 1993). Many of these protocols are based upon the removal ex vivo of either the neoplastic or immune effector cells from the patient, their genetic manipulation in vitro and then their subsequent return to the ...
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Poly(ADP-Ribose) polymerase (PARP) inhibitors: Exploiting a synthetic lethal strategy in the clinic
Ca-A Cancer Journal for Clinicians, 2011Timothy A Yap, Johann Sebastian de Bono
exaly