Results 191 to 200 of about 12,497,887 (407)
Immune Responses to Viral Gene Therapy Vectors
Molecular Therapy, 2020 Jamie L. Shirley +3 more
semanticscholar +1 more source
Exploring the role of cyclin D1 in the pathogenesis of multiple myeloma beyond cell cycle regulation
Molecular Oncology, EarlyView.Cyclin D1 overexpression altered the cell adhesion pathway, while cyclin D2 upregulation had less impact on pathway enrichment analysis. Multiple myeloma (MM) patients with cyclin D1 overexpression showed reduced CD56 expression and increased circulating tumor cells (CTC) levels, suggesting that cyclin D1 may contribute to MM cell dissemination ...
Ignacio J. Cardona‐Benavides +13 more
wiley +1 more source
Possibilities of gene therapy for treatment and prevention of mass pathologies [PDF]
, 1990 В. А. Кордюм
openalex +1 more source
Adeno-associated virus vector as a platform for gene therapy delivery
Nature reviews. Drug discovery, 2019 Dan Wang, P. Tai, G. Gao
semanticscholar +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
OncoImmunologyCAR-based cell therapies have shown clinical success in treating various cancers, with CAR T cell therapies entering the clinical route and CAR NK cell therapies being evaluated in early-stage clinical trials.
Katharina Schindler-Wnek +5 more
doaj +1 more source
NIH seeks bids for vector centres for gene therapy [PDF]
, 1994 Helen Gavaghan
openalex +1 more source
Gene Therapy Evolution: How Gene Therapy has Evolved Preventive Medicine [PDF]
, 2014 Gene therapy technologies offers a prospect for preventive medicine; before the trait can harm the recipient, genetically engineered transgenes will either alter the genetic disorder beforehand, or allow for regeneration of the tissue.
Shah, Kayuri
core +1 more source
Molecular Oncology, EarlyView.Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li +12 more
wiley +1 more source
Liver fibrosis negatively impacts in vivo gene transfer to murine hepatocytes
Nature CommunicationsLiver fibrosis occurs in several genetic and acquired disease conditions, leading to alterations of the tissue and metabolism, which may adversely affect viral vector-mediated gene therapy.
Chiara Simoni +12 more
doaj +1 more source