Results 311 to 320 of about 12,313,232 (386)

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Harnessing the promises of cell therapy, gene therapy, and regenerative medicine in Québec, Canada. [PDF]

Front Med (Lausanne)
Delisle JS, Fournier D, Santerre K, Rochette S, Zawati MH, Dumont-Lagacé M, Turcotte S, Guertin JR, Vermette P, Tremblay JP, Parisotto M, Beauséjour C, Petropoulos L, Kekre N, Michaud S, Dieudé M.   +15 more
europepmc   +1 more source

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

Access to gene therapy for sickle cell disease in Africa. [PDF]

EBioMedicine
Makani J, Bukini D, Malangahe S, Arnold SD, Patel S, Rifai A, Moshi G.   +6 more
europepmc   +1 more source

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

Advances in Precision Therapeutics and Gene Therapy Applications for Retinal Diseases: Impact and Future Directions. [PDF]

Genes (Basel)
AlEissa MM, Alhawsawi AA, Alonazi R, Magharbil E, Aljahdali A, AlBalawi HB, Alali NM, Hameed S, Abu-Amero KK, Magliyah MS.   +9 more
europepmc   +1 more source

Intra-articular IL-4 gene therapy in arthritis: anti-inflammatory effect and enhanced Th2activity

, 1999
D L Boyle, Kathy Nguyen, Shi‐Mei Zhuang, Yunying Shi, James E. McCormack, Sunil Chada, Gary S. Firestein   +6 more
openalex   +1 more source

The role of circular RNAs in regulating cytokine signaling in cancer

FEBS Open Bio, EarlyView.
Cytokines present in the tumor microenvironment fuel cancer development. Aberrant expression of circRNAs contributes to cancer progression. Cytokines are involved in regulating circRNA biogenesis. Furthermore, aberrantly expressed circRNAs regulate the expression of ligands, receptors, and downstream effectors involved in cytokine signaling to promote ...
Vandana Joshi, Swati, Amit Mishra, Amaresh Panda, Vivek Sharma   +4 more
wiley   +1 more source

Identifying prognostic targets in metastatic prostate cancer beyond AR

FEBS Open Bio, EarlyView.
Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng, Eric Feng, Tracy Berg, Isabella S. Nguyen, Lilac G. Nguyen, William Chen, Meng Zhang, David Quigley, Marina Sharifi, Haolong Li, Ilsa Coleman, Peter S. Nelson, Martin Sjöström, Shuang G. Zhao   +13 more
wiley   +1 more source

Gene Therapy in Diabetic Retinopathy and Diabetic Macular Edema: An Update. [PDF]

J Clin Med
Odio-Herrera M, Orozco-Loaiza G, Wu L.
europepmc   +1 more source