Results 311 to 320 of about 12,497,887 (407)

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

Development of Two In Vitro ND1-LHON Models for Evaluating Gene Therapy Efficacy. [PDF]

Invest Ophthalmol Vis Sci
Li X, Yuan J, Chen Z, Zhang Y, Liu Y, Zhang Y.   +5 more
europepmc   +1 more source

Herpes Simplex Virus Thymidine Kinase-Green Fluorescent Protein Fusion Gene: New Tool for Gene Transfer Studies and Gene Therapy

, 1998
Sami Loimas, Jarmo Wahlfors, Juhani Jänne   +2 more
openalex   +1 more source

An efficient strategy for producing RNA‐free Nucleocapsid protein of SARS‐CoV‐2 for biochemical and structural investigations

FEBS Open Bio, EarlyView.
Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley   +1 more source

Gene Therapy for Cardiac Arrhythmias: Mechanisms, Modalities and Therapeutic Applications. [PDF]

Med Sci (Basel)
Karakasis P, Theofilis P, Vlachakis PK, Milaras N, Kalinderi K, Patoulias D, Antoniadis AP, Fragakis N.   +7 more
europepmc   +1 more source

Potential use of herpes simplex virus (HSV) vectors for gene therapy of neurological disorders

, 1997
Peter G. E. Kennedy
openalex   +1 more source

Two‐way inhibition of PAX5 transcriptional activity by PAX5::CBFA2T3

FEBS Open Bio, EarlyView.
PAX5::CBFA2T3 (PAX5‐C) is a fusion protein of the B‐cell transcription factor, PAX5, and is found in B‐cell ALL. We propose a putative model of two‐way inhibition of PAX5 transcriptional activity by PAX5‐C. There are two ways of repression by PAX5‐C: DNA‐binding‐dependent way and HDAC‐dependent way, with either being sufficient for the repression. HDAC
Reina Ueno, Aki Terasaki, Yuiko Imai, Yuri Kimura, Yuna Kojima, Misa Irie, Koya Odaira, Mina Noura, Shuichi Okamoto, Takahiko Yasuda, Shinobu Tsuzuki, Hitoshi Kiyoi, Fumihiko Hayakawa   +12 more
wiley   +1 more source

AAV-Based Gene Therapy: Opportunities, Risks, and Scale-Up Strategies. [PDF]

Int J Mol Sci
Moldavskii D, Gilazieva Z, Fattakhova A, Solovyeva V, Issa S, Sufianov A, Sufianova G, Rizvanov A.   +7 more
europepmc   +1 more source

Cooperative therapeutic effects of androgen ablation and adenovirus-mediated herpes simplex virus thymidine kinase gene and ganciclovir therapy in experimental prostate cancer

, 1999
Simon J. Hall, Steven E. Mutchnik, Guang Yang, Terry L. Timme, Yasutomo Nasu, Chris H. Bangma, Savio L.C. Woo, Mohammed Shaker, Timothy C. Thompson   +8 more
openalex   +1 more source