Results 361 to 370 of about 12,497,887 (407)
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2007
Gene transfer is a therapeutic strategy which uses genetic information, usually in the form of DNA, to modify the phenotype of cells. Gene therapy strategies can be useful for tissue engineering by modifying cells directly or providing a favorable growth environment for the engineered tissue.
Ronald G. Crystal, Stefan Worgall
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Gene transfer is a therapeutic strategy which uses genetic information, usually in the form of DNA, to modify the phenotype of cells. Gene therapy strategies can be useful for tissue engineering by modifying cells directly or providing a favorable growth environment for the engineered tissue.
Ronald G. Crystal, Stefan Worgall
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The Journal of Dermatology, 2001
AbstractWith recent advances in molecular biology, the ability to transfer genes to patients is becoming a reality. Ongoing clinical trials using gene transfer techniques have illustrated the potential and pitfalls of this new therapeutic modality for the treatment of a wide variety of disorders.
E V, Badiavas, V, Falanga
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AbstractWith recent advances in molecular biology, the ability to transfer genes to patients is becoming a reality. Ongoing clinical trials using gene transfer techniques have illustrated the potential and pitfalls of this new therapeutic modality for the treatment of a wide variety of disorders.
E V, Badiavas, V, Falanga
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Annual Review of Neuroscience, 2013
Sight-restoring therapy for the visually impaired and blind is a major unmet medical need. Ocular gene therapy is a rational choice for restoring vision or preventing the loss of vision because most blinding diseases originate in cellular components of the eye, a compartment that is optimally suited for the delivery of genes, and many of these diseases
Sahel José-Alain, Roska Botond
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Sight-restoring therapy for the visually impaired and blind is a major unmet medical need. Ocular gene therapy is a rational choice for restoring vision or preventing the loss of vision because most blinding diseases originate in cellular components of the eye, a compartment that is optimally suited for the delivery of genes, and many of these diseases
Sahel José-Alain, Roska Botond
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DNAzyme-Loaded Metal-Organic Frameworks (MOFs) for Self-Sufficient Gene Therapy.
Angewandte Chemie, 2019DNAzymes have been recognized as potent therapeutic agents for gene therapy, while their inefficient intracellular delivery and insufficient cofactor supply precludes their practical biological applications.
Huimin Wang +5 more
semanticscholar +1 more source
Public Acceptability of Gene Therapy and Gene Editing for Human Use: A Systematic Review
Human Gene Therapy, 2019Gene therapy and gene editing technologies are complex and it can be difficult for the public to understand their possible benefits or side effects. However, patient and public support is critical for the successful adoption of any new technology.
J. Delhove +3 more
semanticscholar +1 more source
Surgical Oncology Clinics of North America, 1998
Developments in molecular genetics, immunology, molecular and cellular biology, and tumor biology have given rise to the field of cancer gene therapy. Several gene delivery vehicles have been developed and are being examined in clinical trials. Most cancer gene therapy strategies involve introduction of genes to augment existing therapies.
Kenneth K. Tanabe, James C. Cusack
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Developments in molecular genetics, immunology, molecular and cellular biology, and tumor biology have given rise to the field of cancer gene therapy. Several gene delivery vehicles have been developed and are being examined in clinical trials. Most cancer gene therapy strategies involve introduction of genes to augment existing therapies.
Kenneth K. Tanabe, James C. Cusack
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2012
During the last 10 years, gene therapy for brain tumors has known peaks and valleys. The first attempts to induce therapeutic effect, using retrovirus to transduce the HSV-TK gene and adenovirus to transfer wild-type p53 cDNA, failed significantly to improve the survival of the patients. In both cases, the failure was attributed to vector deficiencies,
Hong Jiang +4 more
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During the last 10 years, gene therapy for brain tumors has known peaks and valleys. The first attempts to induce therapeutic effect, using retrovirus to transduce the HSV-TK gene and adenovirus to transfer wild-type p53 cDNA, failed significantly to improve the survival of the patients. In both cases, the failure was attributed to vector deficiencies,
Hong Jiang +4 more
openaire +3 more sources
Nursing Clinics of North America, 2000
Gene therapy represents a fundamentally new way to treat disease. Originally conceived as an approach to hereditary disease, it is now being applied to a broad range of acquired conditions such as infections, cancers, and degenerative disorders. A current overview of gene therapy is presented in this article, including descriptions of two clinical ...
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Gene therapy represents a fundamentally new way to treat disease. Originally conceived as an approach to hereditary disease, it is now being applied to a broad range of acquired conditions such as infections, cancers, and degenerative disorders. A current overview of gene therapy is presented in this article, including descriptions of two clinical ...
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Molecular and Cellular Biochemistry, 1984
A number of techniques are available for insertion of new genetic information into mammalian cells. some of these have been used successfully for genetic modification of germ line cells and somatic cells of living animals. Some of these techniques may be applicable to treatment of some of the genetic diseases of man, once problems related to the ...
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A number of techniques are available for insertion of new genetic information into mammalian cells. some of these have been used successfully for genetic modification of germ line cells and somatic cells of living animals. Some of these techniques may be applicable to treatment of some of the genetic diseases of man, once problems related to the ...
openaire +2 more sources
Gene therapy for phenylketonuria
European Journal of Pediatrics, 1994Classical phenylketonuria (PKU) is an autosomal recessive disorder caused by a deficiency of hepatic phenylalanine hydroxylase (PAH). Three different vector systems have been developed to examine the potential of somatic gene therapy for the treatment of PKU.
Savio L. C. Woo, RC Eisensmith
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