Results 361 to 370 of about 12,313,232 (386)
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DNAzyme-Loaded Metal-Organic Frameworks (MOFs) for Self-Sufficient Gene Therapy.
Angewandte Chemie, 2019DNAzymes have been recognized as potent therapeutic agents for gene therapy, while their inefficient intracellular delivery and insufficient cofactor supply precludes their practical biological applications.
Huimin Wang +5 more
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Public acceptability of gene therapy and gene editing for human use: A systematic review.
Human Gene Therapy, 2019Gene therapy and gene editing technologies are complex and it can be difficult for the public to understand their possible benefits or side-effects. However, patient and public support are critical for the successful adoption of any new technology. Given
J. Delhove +3 more
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Surgical Oncology Clinics of North America, 1998
Developments in molecular genetics, immunology, molecular and cellular biology, and tumor biology have given rise to the field of cancer gene therapy. Several gene delivery vehicles have been developed and are being examined in clinical trials. Most cancer gene therapy strategies involve introduction of genes to augment existing therapies.
Kenneth K. Tanabe, James C. Cusack
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Developments in molecular genetics, immunology, molecular and cellular biology, and tumor biology have given rise to the field of cancer gene therapy. Several gene delivery vehicles have been developed and are being examined in clinical trials. Most cancer gene therapy strategies involve introduction of genes to augment existing therapies.
Kenneth K. Tanabe, James C. Cusack
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2012
During the last 10 years, gene therapy for brain tumors has known peaks and valleys. The first attempts to induce therapeutic effect, using retrovirus to transduce the HSV-TK gene and adenovirus to transfer wild-type p53 cDNA, failed significantly to improve the survival of the patients. In both cases, the failure was attributed to vector deficiencies,
Hong Jiang +4 more
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During the last 10 years, gene therapy for brain tumors has known peaks and valleys. The first attempts to induce therapeutic effect, using retrovirus to transduce the HSV-TK gene and adenovirus to transfer wild-type p53 cDNA, failed significantly to improve the survival of the patients. In both cases, the failure was attributed to vector deficiencies,
Hong Jiang +4 more
openaire +3 more sources
The First Approved Gene Therapy Product for Cancer Ad-p53 (Gendicine): 12 Years in the Clinic.
Human Gene Therapy, 2018Gendicine (recombinant human p53 adenovirus), developed by Shenzhen SiBiono GeneTech Co. Ltd., was approved in 2003 by the China Food and Drug Administration (CFDA) as a first-in-class gene therapy product to treat head and neck cancer, and entered the ...
Weiwei Zhang +12 more
semanticscholar +1 more source
Nursing Clinics of North America, 2000
Gene therapy represents a fundamentally new way to treat disease. Originally conceived as an approach to hereditary disease, it is now being applied to a broad range of acquired conditions such as infections, cancers, and degenerative disorders. A current overview of gene therapy is presented in this article, including descriptions of two clinical ...
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Gene therapy represents a fundamentally new way to treat disease. Originally conceived as an approach to hereditary disease, it is now being applied to a broad range of acquired conditions such as infections, cancers, and degenerative disorders. A current overview of gene therapy is presented in this article, including descriptions of two clinical ...
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Molecular and Cellular Biochemistry, 1984
A number of techniques are available for insertion of new genetic information into mammalian cells. some of these have been used successfully for genetic modification of germ line cells and somatic cells of living animals. Some of these techniques may be applicable to treatment of some of the genetic diseases of man, once problems related to the ...
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A number of techniques are available for insertion of new genetic information into mammalian cells. some of these have been used successfully for genetic modification of germ line cells and somatic cells of living animals. Some of these techniques may be applicable to treatment of some of the genetic diseases of man, once problems related to the ...
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The Landscape of Cellular and Gene Therapy Products: Cost, Approvals, and Discontinuations.
Human Gene Therapy Clinical Development, 2019Background The past 10 years witnessed a significant increase in the approval of cellular and gene therapy products worldwide. The US Food and Drug Administration (FDA) approved 3 gene therapy products within the last 4 months of 2017.
V. Shukla +4 more
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Gene therapy for phenylketonuria
European Journal of Pediatrics, 1994Classical phenylketonuria (PKU) is an autosomal recessive disorder caused by a deficiency of hepatic phenylalanine hydroxylase (PAH). Three different vector systems have been developed to examine the potential of somatic gene therapy for the treatment of PKU.
Savio L. C. Woo, RC Eisensmith
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Engineering adeno-associated virus vectors for gene therapy
Nature reviews genetics, 2020Chengwen Li, R. Samulski
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