Results 71 to 80 of about 2,049,710 (211)

Identifying microRNA determinants of human myelopoiesis

Scientific Reports, 2018
Myelopoiesis involves differentiation of hematopoietic stem cells to cellular populations that are restricted in their self-renewal capacity, beginning with the common myeloid progenitor (CMP) and leading to mature cells including monocytes and ...
Megha Rajasekhar, Ulf Schmitz, Stephane Flamant, Justin J.-L. Wong, Charles G. Bailey, William Ritchie, Jeff Holst, John E. J. Rasko   +7 more
doaj   +1 more source

Somatic Gene Therapy

Hematology/Oncology Clinics of North America, 1991
Many problems obviously continue to exist in gene transfer using retroviruses as a means of inserting foreign DNA into hematopoietic stem cells, especially with regulated genes such as the human beta globin genes. First, it is unclear whether the available retroviral vectors will infect enough stem cells for gene transfer to be successful over the long
C, Hesdorffer, D, Markowitz, M, Ward, A, Bank   +3 more
openaire   +2 more sources

ApoE gene therapy: an overview and update [PDF]

, 2005
Atherosclerosis remains the leading cause of death in industrialized societies. Apolipoprotein E (ApoE) is an attractive candidate to treat hypercholesterolemia and coronary heart disease, as it is a circulating protein with pleiotropic ...
Owen, J.S.
core  

Single low-dose cyclophosphamide combined with interleukin-12 gene therapy is superior to a metronomic schedule in inducing immunity against colorectal carcinoma in mice [PDF]

, 2012
The use of conventional cytotoxic agents at metronomic schedules, alone or in combination with targeted agents or immunotherapy, is being explored as a promising anticancer strategy.
Alaniz, Laura Daniela, Aquino, Jorge Benjamin, Atorrasagasti, María Catalina, Bayo Fina, Juan Miguel, Fiore, Esteban Juan, García, Mariana Gabriela, Malvicini, Mariana, Matar, Pablo, Mazzolini Rizzo, Guillermo Daniel, Piccioni, Flavia Valeria   +9 more
core   +1 more source

The antiproliferative ELF2 isoform, ELF2B, induces apoptosis in vitro and perturbs early lymphocytic development in vivo

Journal of Hematology & Oncology, 2017
Background ELF2 (E74-like factor 2) also known as NERF (new Ets-related factor), a member of the Ets family of transcription factors, regulates genes important in B and T cell development, cell cycle progression, and angiogenesis. Conserved ELF2 isoforms,
Fiona H. X. Guan, Charles G. Bailey, Cynthia Metierre, Patrick O’Young, Dadi Gao, Teh Liane Khoo, Jeff Holst, John E. J. Rasko   +7 more
doaj   +1 more source

Combining Transfer of TTF-1 and Pax-8 Gene: a Potential Strategy to Promote Radioiodine Therapy of Thyroid Carcinoma [PDF]

, 2011
Cotransfer of TTF-1 and Pax-8 gene to tumor cells, resulting in the reexpression of iodide metabolism-associated proteins, such as sodium iodide symporter (NIS), thyroglobulin (Tg), thyroperoxidase (TPO), offers the possibility of radioiodine therapy to ...
Anren Kuang, Da Mu, Rui Huang, Suping Li, Xiaojuan Ma   +4 more
core   +1 more source

Generation and characterisation of Friedreich ataxia YG8R mouse fibroblast and neural stem cell models [PDF]

, 2014
This article has been made available through the Brunel Open Access Publishing Fund.Background: Friedreich ataxia (FRDA) is an autosomal recessive neurodegenerative disease caused by GAA repeat expansion in the first intron of the FXN gene, which encodes
A Durr, A Filla, A Halabi, A Hick, A Rotig, A Wong, AH Koeppen, AL Bulteau, AM Khalil, Annalisa Pastore, BL Sopher, C Gellera, C Sandi, CH Zuhlke, Chiranjeevi Sandi, D Marmolino, D Marmolino, D Waldvogel, DH Cho, DW Chung, E Greene, F Foury, G Coppola, G Tan, GS Chandok, H Holemon, H Puccio, H Puccio, H Van Remmen, Harvinder Jassal, I Castaldo, I De Biase, I De Biase, J Du, J Liu, J St-Pierre, JB Schulz, JH Willis, JL Bradley, JL García-Giménez, JP Sarsero, L Grant, L Montermini, L Pianese, L Schols, M Anheim, M Cossee, M Pandolfo, M Perdomini, MA Pook, Madhavi Sandi, Mark A. Pook, ML Moseley, MM Heidari, MM Lufino, MV Evans-Galea, MV Evans-Galea, N Calmels, N Sakamoto, PD Ladd, R Sharma, RA Vaubel, RL Bourn, RM Clark, S Al-Mahdawi, S Al-Mahdawi, S Al-Mahdawi, S Al-Mahdawi, S Ku, Sahar Al-Mahdawi, Sara Anjomani-Virmouni, SW Levison, T Geng, V Campuzano, V Campuzano, V Ezzatizadeh, Vahid Ezzatizadeh, Y Shan   +77 more
core   +2 more sources

P314: Long-term safety and sustained functional benefit in patients with DMD 4 years post-treatment with delandistrogene moxeparvovec: A phase 1/2a study*

Genetics in Medicine Open, 2023
Erin O’Rourke, Jerry R. Mendell, Zarife Sahenk, Kelly J. Lehman, Linda P. Lowes, Natalie F. Reash, Megan Iammarino, Lindsay Alfano, Sarah Lewis, Kathleen Church, Richard Shell, Rachael A. Potter, Danielle Griffin, Mark J. Hogan, Shufang Wang, Stefanie Mason, Eddie Darton, Louise Rodino-Klapac   +17 more
doaj   +1 more source

ProteinCoLoc streamlines Bayesian analysis of colocalization in microscopic images

Scientific Reports
Colocalization, the spatial overlap of molecular entities, is often key to support their involvement in common functions. Existing colocalization tools, however, face limitations, particularly because of their basic statistical analysis and their low ...
Manuel Seefelder, Stefan Kochanek, Fabrice A. C. Klein   +2 more
doaj   +1 more source

Antiangiogenic gene therapy [PDF]

Proceedings of the National Academy of Sciences, 1998
The authors (1) laid the foundation for this experiment by previously showing that a single injection of soluble Tie2 receptor protein into a rat cutaneous window reduced tumor vascular length by 40% …
openaire   +2 more sources