Results 51 to 60 of about 2,049,710 (211)
Mesenchymal stem cell therapy for liver disease: full of chances and challenges
Cell & Bioscience, 2020 Liver disease is a major health problem that endangers human health worldwide. Currently, whole organ allograft transplantation is the gold standard for the treatment of end-stage liver disease.
Xue Yang +5 more
doaj +1 more source
Stochastic models and numerical algorithms for a class of regulatory gene networks [PDF]
, 2008 Regulatory gene networks contain generic modules like those involving feedback loops, which are essential for the regulation of many biological functions.
Fournier, Thomas +5 more
core +2 more sources
Aurintricarboxylic acid increases yield of HSV-1 vectors
Molecular Therapy: Methods & Clinical Development, 2014 Production of large quantities of viral vectors is crucial for the success of gene therapy in the clinic. There is a need for higher titers of herpes simplex virus-1 (HSV-1) vectors both for therapeutic use as well as in the manufacturing of clinical ...
Peter Pechan +5 more
doaj +1 more source
Scientific Reports, 2021 A promising therapy for patients with B-cell lymphoma is based on vaccination with idiotype monoclonal antibodies (mAbs). Since idiotypes are different in each tumor, a personalized vaccine has to be produced for each patient.
Erkuden Casales +11 more
doaj +1 more source
FGF21 gene therapy as treatment for obesity and insulin resistance
EMBO Molecular Medicine, 2018 Prevalence of type 2 diabetes (T2D) and obesity is increasing worldwide. Currently available therapies are not suited for all patients in the heterogeneous obese/T2D population, hence the need for novel treatments.
Veronica Jimenez +23 more
doaj +1 more source
Autoimmune dysregulation and purine metabolism in adenosine deaminase (ADA)-deficiency
Frontiers in Immunology, 2012 Genetic defects in the adenosine deaminase (ADA) gene are among the most common causes for severe combined immunodeficiency (SCID). ADA-SCID patients suffer from lymphopenia, severely impaired cellular and humoral immunity, failure to thrive and ...
Aisha Vanessa Sauer +5 more
doaj +1 more source
BMC Genomics, 2020 Background Identifying nuclease-induced double-stranded breaks in DNA on a genome-wide scale is critical for assessing the safety and efficacy of genome editing therapies.
Camilo Breton +4 more
doaj +1 more source
Scientific Reports, 2022 High expectations have been set on gene therapy with an AAV-delivered shortened version of dystrophin (µDys) for Duchenne muscular dystrophy (DMD), with several drug candidates currently undergoing clinical trials.
Anna V. Starikova +10 more
doaj +1 more source
Early induction of cytokine release syndrome by rapidly generated CAR T cells in preclinical models
EMBO Molecular MedicineCytokine release syndrome (CRS) is a significant side-effect of conventional chimeric antigen receptor (CAR) T-cell therapy. To facilitate patient accessibility, short-term (st) CAR T cells, which are administered to patients only 24 h after vector ...
Arezoo Jamali +5 more
doaj +1 more source