Results 31 to 40 of about 5,948,874 (305)

MicroRNA-7, synergizes with RORα, negatively controls the pathology of brain tissue inflammation

Journal of Neuroinflammation, 2020
Background Accumulating evidence has documented that microRNA-7 (miR-7) plays an important role in the pathology of various diseases. However, the potential role of miR-7 in brain tissue inflammation (BTI) remains unclear.
Dongxu Yue, Juanjuan Zhao, Huizi Chen, Mengmeng Guo, Chao Chen, Ya Zhou, Lin Xu   +6 more
doaj   +1 more source

Gene therapy. [PDF]

Gut, 1982
Gene therapy is not yet possible, but may become feasible soon, particularly for well understood gene defects. Although treatment of a patient raises no ethical problems once it can be done well, changing the genes of an early embryo is more difficult, controversial and unlikely to be required clinically.
openaire   +4 more sources

Data collection infrastructure for patient outcomes in the UK – opportunities and challenges for cell and gene therapies launching

Journal of Market Access & Health Policy, 2019
Background: Cell and gene therapies are associated with uncertainty around their value claims at launch due to limitations of supporting clinical data; furthermore, their high costs present affordability issues for payers.
Jesper Jørgensen, Laura Mungapen, Panos Kefalas   +2 more
doaj   +1 more source

Functional roles of the membrane-associated AAV protein MAAP

Scientific Reports, 2021
With a limited coding capacity of 4.7 kb, adeno-associated virus (AAV) genome has evolved over-lapping genes to maximise the usage of its genome. An example is the recently found ORF in the cap gene, encoding membrane-associated accessory protein (MAAP),
Lionel Galibert, Amira Hyvönen, Reetta A. E. Eriksson, Salla Mattola, Vesa Aho, Sami Salminen, Justin D. Albers, Sanna K. Peltola, Saija Weman, Tiina Nieminen, Seppo Ylä-Herttuala, Hanna P. Lesch, Maija Vihinen-Ranta, Kari J. Airenne   +13 more
doaj   +1 more source

Is it ‘gene therapy’?

Journal of Law and the Biosciences, 2018
What, exactly, is "gene therapy"? Crystallizing a modern definition of "gene therapy" has now become critically important on several fronts. Following the recent of passage the 21st Century Cures Act, FDA now relies on the term to give regulatory incentives to sponsors of certain ‘regenerative medicines’, including ‘gene therapies’.
Jacob S Sherkow, Patricia J Zettler, Henry T Greely   +2 more
openaire   +3 more sources

Gene Therapy for Allergic Diseases

, 2010
Allergic diseases, such as allergic asthma, allergic rhinitis, atopic dermatitis, conjunctivitis, urticaria, food allergy, and/or anaphylaxis, are associated with the skewing of immune responses towards a T helper 2 ( TH2) phenotype, resulting in ...
莊雅惠;楊曜旭;江伯倫, CHUANG, YA-HUI;YANG, YAO-HSU;CHIANG, BOR-LUEN   +1 more
core   +1 more source

Combinatorial gene therapy induces regression of hepatic encephalopathy

, 2010
Capillarization of the sinusoid impedes the clearance of neurotoxic substances in liver fibrosis. These events may result in hepatic encephalopathy. Neurological and hepatic features of rats after bile duct ligation (BDL) supplemented with Manganese ...
A Salazar-Montes, Gonzalez, H., Gonzalez-Garcia, I., Segura-Flores, A., Beas-Zárate, Carlos, V Chaparro-Huerta, Chaparro-Huerta, V., H González, S Lucano-Landeros, Sandoval-Rodriguez, A.S., I Gonzalez-Garcia, Salazar-Montes, A., M Bueno-Topete, D Medina-Preciado, A Segura-Flores, Galvez-Gastelum, F.J., C Beas-Zárate, F J Gálvez-Gastélum, A S Sandoval-Rodriguez, Medina-Preciado, D., Garcia-Bauelos, J.J., J J Garcia-Bañuelos, Bueno-Topete, M., Lucano-Landeros, S., J Armendáriz-Borunda, Armendariz-Borunda, J.   +25 more
core   +1 more source

Inhibition of type I interferon signaling is a conserved function of gamma-herpesvirus-encoded microRNAs

Journal of Virology
Herpesviruses encode multiple factors that disarm innate immune signaling to evade host anti-viral responses. Several viral microRNAs expressed by Epstein-Barr virus (EBV) and Kaposi’s sarcoma-associated herpesvirus (KSHV) disrupt the induction of type I
Devin N. Fachko, Yan Chen, Nikita S. Ivanov, Bonnie Goff, Brian Pendergrass, Darby G. Oldenburg, Ryan D. Estep, Scott W. Wong, Rebecca L. Skalsky   +8 more
doaj   +1 more source

Comparison of two lab-scale protocols for enhanced mRNA-based CAR-T cell generation and functionality

Scientific Reports, 2023
Process development for transferring lab-scale research workflows to automated manufacturing procedures is critical for chimeric antigen receptor (CAR)-T cell therapies.
Nadine von Auw, Robert Serfling, Reni Kitte, Nadja Hilger, Chengkang Zhang, Clara Gebhardt, Anna Duenkel, Paul Franz, Ulrike Koehl, Stephan Fricke, U. Sandy Tretbar   +10 more
doaj   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source