Results 51 to 60 of about 309,008 (294)

Horizontal gene transfer of microbial cellulases into nematode genomes is associated with functional assimilation and gene turnover

BMC Evolutionary Biology, 2011
Background Natural acquisition of novel genes from other organisms by horizontal or lateral gene transfer is well established for microorganisms. There is now growing evidence that horizontal gene transfer also plays important roles in the evolution of ...
Dieterich Christoph, Bartelmes Gabi, Schuster Lisa N, Mayer Werner E, Sommer Ralf J   +4 more
doaj   +1 more source

Metacommunity structure preserves genome diversity in the presence of gene-specific selective sweeps under moderate rates of horizontal gene transfer.

PLoS Computational Biology, 2023
The horizontal transfer of genes is fundamental for the eco-evolutionary dynamics of microbial communities, such as oceanic plankton, soil, and the human microbiome.
Simone Pompei, Edoardo Bella, Joshua S Weitz, Jacopo Grilli, Marco Cosentino Lagomarsino   +4 more
doaj   +1 more source

The early phase of a bacterial insertion sequence infection [PDF]

, 2010
Bacterial insertion sequences are the simplest form of autonomous mobile DNA. It is unknown whether they need to have beneficial effects to infect and persist in bacterial populations, or whether horizontal gene transfer suffices for their persistence ...
Andreas Wagner, Andrew D. Barbour, Athreya, Basten, Berg, Bergthorsson, Blot, Chandler, Charlesworth, Dahlberg, Dawkins, Doolittle, Dröge, Egner, Feller, Fisher, Galas, Gibbons, Gogarten, Haccou, Haldane, Hall, Harris, Jagers, Jiang, Johnson, Kendall, Kimmel, Kimura, Kleckner, Manuel Bichsel, Mayaux, McClintock, Moody, Moran, Nuzhdin, Ohta, Orgel, Powell, R Development Core Team, Savageau, Sawyer, Schneider, Sewastjanow, Shapiro, So, Sørensen, Tavakoli, Thompson, Top, Touchon, Wagner, Wagner, Williams, Zerbib   +54 more
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Horizontal gene transfer contributes to plant evolution : the case of Agrobacterium T-DNAs [PDF]

, 2017
Horizontal gene transfer (HGT) can be defined as the acquisition of genetic material from another organism without being its offspring. HGT is common in the microbial world including archaea and bacteria, where HGT mechanisms are widely understood and ...
Gheysen, Godelieve, Kreuze, Jan F, Quispe Huamanquispe, Dora   +2 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

A probabilistic model for gene content evolution with duplication, loss, and horizontal transfer

, 2005
We introduce a Markov model for the evolution of a gene family along a phylogeny. The model includes parameters for the rates of horizontal gene transfer, gene duplication, and gene loss, in addition to branch lengths in the phylogeny. The likelihood for
A.B. Simonson, B. Boussau, B. Snel, B. Snel, B.E. Dutilh, B.G. Mirkin, C. Pál, C.G. Kurland, D.H. Huson, E. Belda, E.A. Herniou, E.D. Green, E.J. Deeds, E.L.L. Sonnhammer, E.V. Koonin, F. Delsuc, F. Tekaia, G.D.P. Clarke, G.P. Karev, G.P. Karev, G.P. Karev, I.K. Jordan, J. Lin, J.A. Lake, J.O. Korbel, J.P. Gogarten, J.T. Herbeck, K.H. Wolfe, M. Csűrös, M. Pellegrini, M.G. Montague, M.W. Hahn, R.L. Tatusov, S. Karlin, S. Yang, S.T. Fitz-Gibbon, T. Pupko, V. Kunin, V. Kunin, W. Feller, W.J. Reed, X. Gu, Y. Boucher, Y.I. Wolf   +43 more
core   +2 more sources

Massive Horizontal Gene Transfer in Bdelloid Rotifers [PDF]

, 2008
Horizontal gene transfer in metazoans has been documented in only a few species and is usually associated with endosymbiosis or parasitism. By contrast, in bdelloid rotifers we found many genes that appear to have originated in bacteria, fungi, and ...
Arkhipova, Irina, Gladyshev, Evgeniy, Meselson, Matthew   +2 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source