Results 61 to 70 of about 305,994 (296)

The Role of Type VI Secretion System Effectors in Target Cell Lysis and Subsequent Horizontal Gene Transfer [PDF]

, 2017
Bacteria use type VI secretion systems (T6SSs) to manipulate host cells during pathogenesis or to kill competing bacteria, which, in some cases, increases horizontal gene transfer.
Basler, Marek, Hu, Di, Ringel, Peter David   +2 more
core   +2 more sources

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Loss of very-long O-antigen chains optimizes capsule-mediated immune evasion by Salmonella enterica serovar Typhi. [PDF]

, 2013
UnlabelledExpression of capsular polysaccharides is a variable trait often associated with more-virulent forms of a bacterial species. For example, typhoid fever is caused by the capsulated Salmonella enterica serovar Typhi, while nontyphoidal Salmonella
Bäumler, Andreas J, Crawford, Robert W, Spees, Alanna M, Tsolis, Renée M, Wangdi, Tamding, Xavier, Mariana N   +5 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Genomic islands: tools of bacterial horizontal gene transfer and evolution [PDF]

, 2017
Bacterial genomes evolve through mutations, rearrangements or horizontal gene transfer. Besides the core genes encoding essential metabolic functions, bacterial genomes also harbour a number of accessory genes acquired by horizontal gene transfer that ...
Crook, Derrick W., Gaillard, Muriel, Harding, Rosalind M., Hood, Derek W., Juhas, Mario, van der Meer, Jan Roelof   +5 more
core  

Ancient horizontal gene transfer and the last common ancestors [PDF]

, 2015
Background The genomic history of prokaryotic organismal lineages is marked by extensive horizontal gene transfer (HGT) between groups of organisms at all taxonomic levels. These HGT events have played an essential role in the origin and distribution of
A Barzel, A Burt, A Hua-Van, A Sauerwald, A Stoltzfus, AM Barbaglia, B Boussau, B Reisinger, C Darwin, Cheryl P Andam, CP Andam, CP Andam, CR Woese, CR Woese, D Darriba, D Williams, DA Benson, DH Rothman, EGJ Danchin, EV Koonin, EV Koonin, EV Koonin, G Borrel, G Borrel, G Eriani, G Srinivasan, GJ Szöllosi, GM Nagel, GP Fournier, GP Fournier, GP Fournier, Gregory P Fournier, H Grosjean, J Peretó, J Thomas, JA Krzycki, JA Krzycki, JAG Ranea, JL Siefert, JM Kavran, Johann Peter Gogarten, JP Gogarten, K Swithers, K Vetsigian, L Olendzenski, L Ribas de Pouplana, L Ribas de Pouplana, L Sinzelle, LS Frost, M Ibba, M Khomyakova, M Syvanen, M Wu, MH Mazauric, MV Omelchenko, N Lartillot, N Nameki, O Penn, O Zhaxybayeva, P Kück, P Kück, P O’Donoghue, P O’Donoghue, P Schimmel, R Dawkins, R Jain, RC Edgar, S Bilokapic, S Gould, S Guindon, S Herring, S Herring, S Morris, S Osawa, SQ Le, T Tuller, TJ Treangen, VV Kapitonov, WM Fitch, Y Diaz-Lazcoz, Y Zhang, YI Wolf, Z-P Fang   +82 more
core   +2 more sources

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

FEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić, Darija Putar, Lucija Mijanović, Igor Weber   +3 more
wiley   +1 more source

Horizontal gene transfer in the human gastrointestinal tract: potential spread of antibiotic resistance genes

Infection and Drug Resistance, 2014
Jennifer R HuddlestonBiology Department, Abilene Christian University, Abilene, TX, USAAbstract: Bacterial infections are becoming increasingly difficult to treat due to widespread antibiotic resistance among pathogens.
Huddleston JR
doaj  

Integrating Horizontal Gene Transfer and Common Descent to Depict Evolution and Contrast It with ‘‘Common Design [PDF]

, 2010
Horizontal gene transfer (HGT) and common descent interact in space and time. Because events of HGT co-occur with phylogenetic evolution, it is difficult to depict evolutionary patterns graphically. Tree-like representations of life’s diversification are
Espinosa, Avelina, Paz-y-Mino C., Guillermo   +1 more
core   +2 more sources

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source