Results 81 to 90 of about 560,494 (342)
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance Bacteria can obtain genes from other bacteria, or the surrounding environment, by horizontal gene transfer (HGT). While it is clear that HGT is very important for microbial populations, it is not understood how HGT changes the rate or ...
Laura C. Woods +5 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Horizontal gene transfer contributed to the evolution of extracellular surface structures [PDF]
, 2012 The single-cell layered ectoderm of the fresh water polyp Hydra fulfills the function of an epidermis by protecting the animals from the surrounding medium.
Altstätter, Johannes +13 more
core +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Horizontal gene transfer in bacteria: an ecological and evolutionary perspective
Acta Agriculturae Slovenica, 2000 In recent years, molecular genetics and genome analysis provided extensive evidence that gene loss and acquisition are likely to be the primary mechanisms by which bacteria genetically adapt to novel or changed environments and by which bacterial ...
Matjaž PETERKA +2 more
doaj +1 more source
Evidence of Massive Horizontal Gene Transfer Between Humans and Plasmodium vivax [PDF]
, 2011 The horizontal transfer of DNA between different organisms is a major force shaping the genomes of prokaryotes, but is considered to have a minor role in eukaryotes, with only a handful of known examples, mostly of limited size.
Daniel Z. Bar
core +2 more sources
Horizontal Gene Transfer as a Source of Conflict and Cooperation in Prokaryotes
Frontiers in Microbiology, 2020 Horizontal gene transfer (HGT) is one of the most important processes in prokaryote evolution. The sharing of DNA can spread neutral or beneficial genes, as well as genetic parasites across populations and communities, creating a large proportion of the ...
Rebecca J. Hall +4 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Frontiers in MicrobiologyAntibiotic resistance, projected to cause 10 million deaths annually by 2050, remains a critical health threat. Hospitals drive multidrug resistance via horizontal gene transfer.
Shaday Guerrero-Flores +6 more
doaj +1 more source