Results 201 to 210 of about 1,625,963 (355)

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Horizontal gene transfer, segregation loss, and the speed of microbial adaptation. [PDF]

Evol Lett
McLeod DV, Gandon S.
europepmc   +1 more source

Efficacy, safety, and quality of life 4 years after valoctocogene roxaparvovec gene transfer for severe hemophilia A in the phase 3 GENEr8-1 trial

Andrew D. Leavitt, Johnny Mahlangu, Priyanka Raheja, Emily Symington, Doris Quon, Adam Giermasz, María Fernanda López Fernández, Gili Kenet, Gillian Lowe, Nigel S. Key, Carolyn M. Millar, Steven W. Pipe, Bella Madan, Sheng‐Chieh Chou, Robert Klamroth, Jane Mason, Hérvè Chambost, Flora Peyvandi, Elaine M. Majerus, Dominic Pepperell, Christine Rivat, Hua Yu, Tara M. Robinson, Margareth C. Ozelo   +23 more
openalex   +1 more source

Modeling suggests frequency estimates are not informative for predicting the long-term effect of horizontal gene transfer in bacteria [PDF]

, 2005
Ann-Kathrin Pettersen, Thomas Bøhn, Raul Primicerio, Paul R. Shorten, Tanya K. Soboleva, Kaare Magne Nielsen   +5 more
openalex   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Mechanisms, detection, and impact of horizontal gene transfer in plant functional evolution. [PDF]

Plant Cell
Mariault L, Puginier C, Keller J, El Baidouri M, Delaux PM.   +4 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Nucleic acid-encoded antibody gene transfer-next generation of antibody therapies. [PDF]

Drug Deliv
Yu K, Xiao G, Chen B, Xu N, Liu W.
europepmc   +1 more source

Correction of the Galactocerebrosidase Deficiency in Globoid Cell Leukodystrophy-Cultured Cells by SL3-3 Retroviral-Mediated Gene Transfer

, 1996
Miguel A. Gama Sosa, Rita De Gasperi, Samir D. Undevia, Joseph Yeretsian, Strutha C. Rouse, Timothy A. Lyerla, Edwin H. Kolodny   +6 more
openalex   +1 more source

Horizontal Gene Transfer.

Evolution, medicine, and public health, 2015
openaire   +2 more sources