Results 211 to 220 of about 11,371,695 (398)

Adenovirus-associated virus vector-mediated gene transfer in hemophilia B.

New England Journal of Medicine, 2011
A. Nathwani, E. Tuddenham, S. Rangarajan, Cecilia Rosales, J. McIntosh, D. Linch, P. Chowdary, A. Riddell, Arnulfo Pie, C. Harrington, J. O’Beirne, Keith A. Smith, J. Pasi, B. Glader, P. Rustagi, C. Ng, M. Kay, Junfang Zhou, Yunyu Spence, C. Morton, J. Allay, J. Coleman, S. Sleep, J. Cunningham, D. Srivastava, E. Basner-Tschakarjan, F. Mingozzi, K. High, J. Gray, U. Reiss, A. Nienhuis, A. Davidoff   +31 more
semanticscholar   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Co-occurrence is associated with horizontal gene transfer across marine bacteria independent of phylogeny. [PDF]

ISME J
Douglas GM, Tromas N, Gaudin M, Lypaczewski P, Bobay LM, Shapiro BJ, Chaffron S.   +6 more
europepmc   +1 more source

CRISPR Interference Limits Horizontal Gene Transfer in Staphylococci by Targeting DNA

Science, 2008
L. Marraffini, E. Sontheimer
semanticscholar   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Classifying Convergences in the Light of Horizontal Gene Transfer: Epaktovars and Xenotypes. [PDF]

Mol Biol Evol
McInerney JO.
europepmc   +1 more source

No evidence for extensive horizontal gene transfer in the genome of the tardigrade Hypsibius dujardini

Proceedings of the National Academy of Sciences of the United States of America, 2016
Georgios D. Koutsovoulos, Sujai Kumar, D. Laetsch, L. Stevens, J. Daub, Claire Conlon, H. Maroon, F. Thomas, A. Aboobaker, M. Blaxter   +9 more
semanticscholar   +1 more source

Gene transfer to hepatocellular carcinoma: Transduction efficacy and transgene expression kinetics by using retroviral and lentiviral vectors [PDF]

, 2000
René Gerolami, Rathviro Uch, François Jordier, S. Chapel, Claude Bagnis, Christian Bréchot, P Mannoni   +6 more
openalex   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Genomic Evolution and Patterns of Horizontal Gene Transfer in Coccomorpha Species. [PDF]

Ecol Evol
Huang YX, Lv JM, Ding CY, Zheng XY, Liu XJ, Chen XN, Yu SH, Meng YF, Hu HY, Wang X.   +9 more
europepmc   +1 more source