Results 231 to 240 of about 1,625,963 (355)

161. Novel Gene Transfer Strategy for Hemophilia A by Omental Implantaion of Autologous Endothelial Cell Sheet [PDF]

, 2016
Hideto Matsui, Masahi Noda, Midori Shima, Rie Utoh, Teruo Okano, Mitsuhiko Sugimoto   +5 more
openalex   +1 more source

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

Multiple independent acquisitions of a metallophore-synthesis gene by plants through horizontal microbial gene transfer. [PDF]

Nat Commun
Dirick L, Liu Y, Dong S, Yu J, Ouerdane L, Storti M, Alboresi A, Curie C, Goffinet B.   +8 more
europepmc   +1 more source

Plasmid cost driven by copy number and transfer genotypes is partially alleviated by AMR gene deletion.

Andrew C. Matthews (6480968), Sonja Lehtinen (784974), Tatiana Dimitriu (2822459)   +2 more
openalex   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Mitogenome Characteristics and Intracellular Gene Transfer Analysis of Four <i>Adansonia</i> Species. [PDF]

Genes (Basel)
Hu T, Zhou F, Wang L, Hu X, Li Z, Li X, Zhou D, Wang H.   +7 more
europepmc   +1 more source

Gene transfer to human joints: Progress toward a gene therapy of arthritis

, 2005
Christopher H. Evans, Paul D. Robbins, Steven C. Ghivizzani, Mary Chester Wasko, Matthew M. Tomaino, Richard W. Kang, Thomas A. Muzzonigro, Molly T. Vogt, Elaine M. Elder, Theresa L. Whiteside, Simon C. Watkins, James H. Herndon   +11 more
openalex   +1 more source

Long‐term culture of skin biopsies: maintenance of fibroblast production and competency of reprogramming

FEBS Open Bio, EarlyView.
Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar, Michael A. Ripperger, Grant M. Westlake, Kevin C. Ess   +3 more
wiley   +1 more source

The environmental adaptation of acidophilic archaea: promotion of horizontal gene transfer by genomic islands. [PDF]

BMC Genomics
Qiu J, Tao H, Li H, Liu X, Liu R, Nawaz MN, Wang X, Ma L.   +7 more
europepmc   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source