Results 231 to 240 of about 10,802,441 (400)

Peptide-encoding gene transfer to modulate intracellular protein-protein interactions

Molecular Therapy: Methods & Clinical Development
Peptide drug discovery has great potential, but the cell membrane is a major obstacle when the target is an intracellular protein-protein interaction (PPI). It is difficult to target PPIs with small molecules; indeed, there are no intervention tools that
Toshihiko Taya, Daisuke Kami, Fumiya Teruyama, Satoaki Matoba, Satoshi Gojo   +4 more
doaj  

Environmental DNA adsorption to chitin can promote horizontal gene transfer by natural transformation. [PDF]

Proc Natl Acad Sci U S A
Holt JD, Peng Y, Dalia TN, Dalia AB, Nadell CD.   +4 more
europepmc   +1 more source

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

Loss of Pathogenicity and Evidence of Horizontal Gene Transfer in Colletotrichum gloeosporioides From a Medicinal Plant. [PDF]

Mol Plant Pathol
Yue X, Yang J, Qi J, Gao S, Huo Q, Guo X, Guo H, Luo J, Wang Y, Zhao Y, Liu R, Wang H, Yi S, Fu Y, Ji X, Wei Y, He W, Guo B.   +17 more
europepmc   +1 more source

Recognition of EBV plasma membrane protein expressed on murine cells after gene transfer. [PDF]

, 1987
Carol Shoshkes Reiss, D Wang, Dilip K. Ghosh, C Gaposchkin, Elliott Kieff   +4 more
openalex   +1 more source

The influence of endosome-disruptive peptides on gene transfer using synthetic virus-like gene transfer systems [PDF]

, 1994
Koch, Christian, Mechtler, Karl, Oberhauser, Berndt, Plank, Christian, Wagner, Ernst   +4 more
core  

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

Ancient Host-Virus Gene Transfer Hints at a Diverse Pre-LECA Virosphere. [PDF]

J Mol Evol
Karki S, Barth ZK, Aylward FO.
europepmc   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

NIH delay first gene transfer [PDF]

, 1988
Joseph Palca
openalex   +1 more source