Results 91 to 100 of about 9,648,060 (267)
Актуальні питання суспільних наук та історії медицини, 2014 Skrytska Natalya. The Formation of the Subject Field of Metaphysical Categories in Terms of Philosophical Ideas of Late Scholastics. The article considers the nature of such metaphysical concepts as essence, being, God, substance, logical quantifier ...
Скрицька Наталія
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Innovation and SustainabilityThe article describes methodical approaches to the formation of the strategy of innovative development of industrial enterprises based on the Burennikova (Polishchuk)-Yarmolenko component effectiveness models, which are based on the characteristics of ...
N. Burennikova, I. Vishtak
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
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Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Five-Hundred-Meter Aperture Spherical Radio Telescope (FAST): A Powerful Explorer of Exotic Pulsars
UniverseLocated in southern China, the five-hundred-meter aperture spherical radio telescope (FAST) is the world’s most sensitive radio telescope, especially for pulsar observation. Since its commissioning in 2016 and full operation in 2020, it has detected over
Cheng-Min Zhang +9 more
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Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
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Journal of Pharmacy and Bioallied SciencesBackground: Perimenopausal women often experience neurocognitive fluctuations due to hormonal changes, which may predispose them to cognitive dysfunction following general anesthesia.
Divya Sinha +3 more
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Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source