Results 141 to 150 of about 35,307,983 (380)

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

A randomized controlled trial to compare the percentage of glottic opening score of McGrath MAC® video laryngoscope and C-MAC® video laryngoscope in children

The Indian Anaesthetists' Forum
Background and Aims: Video laryngoscopes (VL) have now an established role in the management of difficult airway. The design of VL blade may affect the tracheal intubation outcomes.
Ranju Singh, K Manikandan, Pooja Singh
doaj   +1 more source

The Practice of Using the Discriminant Analysis of the Efficiency of Processes of Functioning of Agricultural Enterprises on the Basis of Indicators of the Constituent Parts of Performance [PDF]

Bìznes Inform, 2018
The article considers the practice of using the method of discriminant analysis to study effectiveness of the processes of functioning of enterprises on the basis of indicators of the constituent parts of performance on the example of specific ...
Burennikova Nataliia V., Marchuk Lina M.
doaj  

On some general Formulae for the Potentials of Ellipsoids, Shells, and Discs [PDF]

, 1895
E. W. Hobson
openalex   +1 more source

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

Representação do masculino no conto O General Infanciado, de Mia Couto

Revista de Estudos Literários da UEMS - REVELL, 2016
A representação social dentro da literatura traz várias marcas do comportamento humano, uma delas é a masculinidade e a construção social do imaginário do que é ser homem.
Regina Costa Nunes Andrade
doaj  

On certain changes occurring in the voluntary muscles in general diseases [PDF]

, 1912
Reginald C. Jewesbury, W. W. C. Topley
openalex   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

General removal lemma [PDF]

, 2013
We formulate and prove a general result in spirit of hypergraph removal lemma for measurable functions of several variables.Comment: 5 ...
Petrov, Fedor
core  

A general solution for the rectangular airfoil in supersonic flow [PDF]

, 1953
John W. Miles
openalex   +1 more source