Results 151 to 160 of about 10,079,612 (248)

Improving readability of layperson abstracts and summaries in oncology using task-specific large language model powered tool: results from the BRIDGE-AI 7 study. [PDF]

JAMIA Open
Pannu AS, Cano I, Layne E, Miranda G, Cai J, Ganjavi C, Magoulianitis V, Gill K, Fuchs G, Desai M, Gill I, Cacciamani GE.   +11 more
europepmc   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Geriatrician and General Internist Clinical Payments in Canada 2022-2023: Fee for Service and Alternative Payment Plan. [PDF]

Can Geriatr J
Martel AB, Mah JC, Shu KJ, Bhangu JS, Borrie MJ.   +4 more
europepmc   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Neurological Teleconsultations in General Practice: A Stepped-Wedge Cluster Randomized Clinical Trial.

JAMA Neurol
Kiel S, Wainwright KL, Angermaier A, Chenot JF, Wischmann HA, Schulz RS, Filser PJ, Flöel A, Kurth T, von Podewils F.   +9 more
europepmc   +1 more source

Kidney transplantation in sub-Sahara African countries: challenges and lessons from the experience of Cameroon: a preliminary report of the first 17 pioneer cases. [PDF]

Ren Fail
Djientcheu VP, Ashuntantang G, Nono A, Kamga J, Mba S, Ngongang MP, Tebere H, Ngoundjou A, Aghogue T, Essissima F, Tiam M, Fokou M.   +11 more
europepmc   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Long-Term Cardiometabolic Outcomes in Children With Metabolically Healthy and Unhealthy Obesity.

JAMA Pediatr
Putri RR, Danielsson P, Hagman E, Marcus C.   +3 more
europepmc   +1 more source

Life expectancy of cancer patients in China. [PDF]

Mil Med Res
Xia CF, Yang J, Zhou JH, Xu YJ, Chen WQ.
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source