Results 51 to 60 of about 113,505 (257)

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

(In)compatibility of Special Expropriation Procedural Provisions with General Administrative Procedure Act

Zbornik radova Pravnog fakulteta u Splitu, 2017
The principle of consistency and principle of legitimate expectations of citizens are the basis for the treatment of administrative bodies of any national or supranational level. The purpose of this principle is that the administrative bodies, by applying the usual and publicly announced procedure, treat citizens in the same way.
Romić, Danijela, Horvat, Božidar, Vajda Halak, Željka   +2 more
openaire   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Specificities of the property restitution procedure under the law of the Republic of Serbia

Pravo
In all the republics of the former Yugoslavia, including in the Republic of Serbia, property relations were highly dynamic, with the answer to the question of who held ownership rights frequently changing.
Jasna Selaković, Predrag Mirković
doaj   +1 more source

Providing of public services in the field of biomedicine [PDF]

Zbornik Radova: Pravni Fakultet u Novom Sadu, 2018
The paper analyzes one of the new notions in Serbian administrative law, created by the Law on General Administrative Procedure - providing of public services.
Radošević Ratko S.
doaj  

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

CURRENT QUESTIONS OF THE REGULATION OF THE NEW CROATIAN GENERAL ADMINISTRATIVE PROCEDURE

Zbornik Radova Pravnog Fakulteta u Splitu, 2008
The authors answer the question of whether Croatia needs a new General Administrative Procedure Act or whether amendment of the existing one is enough.
Boris Ljubanović, Boris Bakota
doaj  

Concept and classification of administrative material actions: Between theory and legislation [PDF]

Zbornik Radova: Pravni Fakultet u Novom Sadu, 2018
This paper deals with the concept of administrative actions and their classification in the Serbian law. With the adoption of the new Law on General Administrative Procedure in 2016, administrative actions have been defined in this Law.
Jovanović Zoran R.
doaj  

The “coactive procedure” in the ecuadorian legislation of the last years (2005-2018), and its regime in the organic administrative code

Revista Facultad de Jurisprudencia, 2018
The coercive procedure refers to the application of the administrative authority with respect to an obligation that citizens or foreigners contract for various circumstances in a given state; Regarding the administrative procedure, several legal bodies ...
Luis Adrian Serrano
doaj   +1 more source