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Mechanisms of General Anesthesia [PDF]

Environmental Health Perspectives, 1990
Although general anesthetics are often said to be nonspecific agents, it is likely that they act at a much more restricted set of target sites than commonly believed. The traditional view has been that the primary targets are lipid portions of nerve membranes, but recent evidence shows that the effects on lipid bilayers of clinically relevant levels of
William R. Lieb, Nicholas P. Franks
openaire   +3 more sources

Prenatal Exposure to General Anesthesia and Childhood Behavioral Deficit

Anesthesia and Analgesia, 2021
BACKGROUND: Exposure to surgery and anesthesia in early childhood has been found to be associated with an increased risk of behavioral deficits. While the US Food and Drug Administration (FDA) has warned against prenatal exposure to anesthetic drugs ...
C. Ing, R. Landau, David DeStephano, Caleb H. Miles, B. V. von Ungern-Sternberg, Guohua Li, A. Whitehouse   +6 more
semanticscholar   +1 more source

The association between gut microbiota and postoperative delirium in patients

Translational Psychiatry, 2023
Postoperative delirium is a common postoperative complication in older patients, and its pathogenesis and biomarkers remain largely undetermined. The gut microbiota has been shown to regulate brain function, and therefore, it is vital to explore the ...
Yiying Zhang, Kathryn Baldyga, Yuanlin Dong, Wenyu Song, Mirella Villanueva, Hao Deng, Ariel Mueller, Timothy T. Houle, Edward R. Marcantonio, Zhongcong Xie   +9 more
doaj   +1 more source

Dental treatment under general anesthesia for patients with severe disabilities

Journal of dental anesthesia and pain medicine, 2021
Patients with disabilities have difficulties tolerating in-office dental treatment due to limitations relating to cooperation and/or physical problems. Therefore, they often require general anesthesia or sedation to facilitate safe treatment.
Junglim Choi, Re-mee Doh
semanticscholar   +1 more source

Neural Substrates for the Regulation of Sleep and General Anesthesia

Current Neuropharmacology, 2021
General anesthesia has been successfully used in clinics for over 170 years, but its mechanisms of effect remain unclear. Behaviorally, general anesthesia is similar to sleep as it produces a reversible transition between wakefulness and the state of ...
Qianzi Yang, Fang Zhou, Ao Li, Hailong Dong   +3 more
semanticscholar   +1 more source

Anesthetic management of inguinal hernia in an ex-premature infant with subglottic stenosis: a case report

JA Clinical Reports, 2023
Background We report the anesthetic management of inguinal hernia repair for an infant with subglottic stenosis. A previously scheduled operation had been cancelled due to unexpected airway trouble during the induction.
Yumi Doi, Satoshi Ekuni
doaj   +1 more source

Ensuring competency in focused cardiac ultrasound: a systematic review of training programs

Journal of Intensive Care, 2020
Background Focused cardiac ultrasound (FoCUS) is a valuable skill for rapid assessment of cardiac function and volume status. Despite recent widespread adoption among physicians, there is limited data on the optimal training methods for teaching FoCUS ...
Lauren E. Gibson, Gabrielle A. White-Dzuro, Patrick J. Lindsay, Sheri M. Berg, Edward A. Bittner, Marvin G. Chang   +5 more
doaj   +1 more source

Sleep and general anesthesia [PDF]

Canadian Journal of Anesthesia/Journal canadien d'anesthésie, 2010
The mechanisms through which general anesthetics cause reversible loss of consciousness are characterized poorly. In this review, we examine the evidence that anesthetic-induced loss of consciousness may be caused by actions on the neuronal pathways that produce natural sleep.It is clear that many general anesthetics produce effects in the brain ...
Anna Y. Zecharia, Nicholas P. Franks
openaire   +2 more sources

Recovery of consciousness and cognition after general anesthesia in humans

bioRxiv, 2020
Understanding how consciousness and cognitive function return after a major perturbation is important clinically and neurobiologically. To address this question, we conducted a three-center study of 30 healthy humans receiving general anesthesia at ...
G. Mashour, B. Palanca, M. Basner, Duan Li, Wei Wang, S. Blain-Moraes, N. Lin, Kaitlyn L. Maier, M. Muench, V. Tarnal, G. Vanini, E. Ochroch, Rosemary Hogg, Marlon Schwartz, H. Maybrier, Randall Hardie, E. Janke, Goodarz Golmirzaie, P. Picton, A. McKinstry-Wu, M. Avidan, M. Kelz   +21 more
semanticscholar   +1 more source

Oral Administration of Glutathione Trisulfide Increases Reactive Sulfur Levels in Dorsal Root Ganglion and Ameliorates Paclitaxel-Induced Peripheral Neuropathy in Mice

Antioxidants, 2022
Peripheral neuropathy is a dose-limiting side effect of chemotherapy with paclitaxel. Paclitaxel-induced peripheral neuropathy (PIPN) is typically characterized by a predominantly sensory neuropathy presenting with allodynia, hyperalgesia and spontaneous
Mariko Ezaka, Eizo Marutani, Yusuke Miyazaki, Eiki Kanemaru, Martin K. Selig, Sophie L. Boerboom, Katrina F. Ostrom, Anat Stemmer-Rachamimov, Donald B. Bloch, Gary J. Brenner, Etsuo Ohshima, Fumito Ichinose   +11 more
doaj   +1 more source