Results 71 to 80 of about 7,027,212 (415)

Polydatin ameliorates ovalbumin‐induced asthma in a rat model through NCOA4‐mediated ferroautophagy and ferroptosis pathway

FEBS Open Bio, EarlyView.
In this research, a rat model of asthma was created using OVA, and polydatin served as an intervention. By inhibiting ferroautophagy mediated by NCOA4 and averting ferroptosis, polydatin has been demonstrated to reduce asthma. This work presents new ideas for investigating the mechanism of polydatin's ability to alleviate asthma, in addition to ...
Wei Li, Yuwei Tang, Wenkang Liu, Fang Fang, Jiepeng Wang, Chaoyi Fang   +5 more
wiley   +1 more source

Influence of Isoflurane on Immediate-Early Gene Expression [PDF]

, 2016
Background: Anterograde amnesia is a hallmark effect of volatile anesthetics. Isoflurane is known to affect both the translation and transcription of plasticity-associated genes required for normal memory formation in many brain regions.
Almira Vazdarjanova, Kristopher M. Bunting, Rebecca I. Nalloor   +2 more
core   +1 more source

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source

Possible iodophor-induced systemic iodine toxicity during transurethral seminal vesiculoscopy: a case report and literature review

BMC Urology
Rationale Iodophor, a disinfectant composed of iodine complexed with a surfactant, is extensively employed for preoperative skin preparation, burn wound management, and mucosal disinfection.
Meng Zhang, Nan Zhao, Huanhuan Zhang, Jianli Li   +3 more
doaj   +1 more source

Improving the accuracy of revised cardiac risk index with HbA1C: Hemoglobin ratio (HH ratio) – A retrospective cohort study

Frontiers in Medicine, 2023
BackgroundThe current Lee’s Revised cardiac risk index (RCRI) was created in 1999. Validation studies have found RCRI to be only moderately discriminant.
Yuhe Ke, Nicholas Brian Shannon, Hairil Rizal Abdullah   +2 more
doaj   +1 more source

Protocol for the Reconstructing Consciousness and Cognition (ReCCognition) Study [PDF]

, 2017
Important scientific and clinical questions persist about general anesthesia despite the ubiquitous clinical use of anesthetic drugs in humans since their discovery.
Andrew R. McKinstry-Wu, Ben Julian A. Palanca, George A. Mashour, Kaitlyn L. Maier, Mathias Basner, Mathias Basner, Max B. Kelz, Max B. Kelz, Michael S. Avidan, Stefanie Blain-Moraes, Vijay Tarnal   +10 more
core   +3 more sources

Longitudinal Relationship Between Pain and Depression in People With Inflammatory Arthritis: A Narrative Review

Arthritis Care &Research, EarlyView.
As many patients with inflammatory arthritis (IA) have chronic pain, understanding how to best assess and manage pain in IA is a priority. Comorbid depression is prevalent in adults with IA, affecting 15% to 39% of people. Although pain and depression are thought to be associated in IA, this concept is largely based on cross‐sectional data.
Natasha Cox, Saeed Farooq, Helen Twohig, Ian C. Scott   +3 more
wiley   +1 more source

Efficiency of spinal anesthesia versus general anesthesia for lumbar spinal surgery: a retrospective analysis of 544 patients. [PDF]

, 2017
BACKGROUND: Previous studies have shown varying results in selected outcomes when directly comparing spinal anesthesia to general in lumbar surgery. Some studies have shown reduced surgical time, postoperative pain, time in the postanesthesia care unit ...
Attiah, Mark A., Kallan, Michael J., Koenigsberg, Rebecca, Kofke, W. Andrew, Kositratna, Guy, Marcotte, Paul J., Pierce, John T., Syre, Peter, Welch, William C., Wyler, MD, David   +9 more
core   +1 more source

Metabolic Consequences of Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Patients with rheumatoid arthritis (RA) may have metabolic disruption, which can contribute to adverse long‐term outcomes, for multiple reasons. Patients with RA appear to have a higher risk of sarcopenia, type 1 and type 2 diabetes mellitus, metabolic syndrome, and hypertension. Systemic inflammation in RA can cause a “lipid paradox,” with reduced low‐
Stevie Barry, Emily Sheng, Joshua F. Baker   +2 more
wiley   +1 more source

Neuropsychological and Behavioral Outcomes after Exposure of Young Children to Procedures Requiring General Anesthesia: The Mayo Anesthesia Safety in Kids (MASK) Study

Anesthesiology, 2018
Background: Few studies of how exposure of children to anesthesia may affect neurodevelopment employ comprehensive neuropsychological assessments. This study tested the hypothesis that exposure to multiple, but not single, procedures requiring anesthesia
D. O. Warner, Michael J. Zaccariello, S. Katusic, D. Schroeder, A. Hanson, P. Schulte, Shonie L. Buenvenida, S. Gleich, R. Wilder, J. Sprung, Danqing Hu, R. Voigt, M. Paule, J. Chelonis, R. Flick   +14 more
semanticscholar   +1 more source