Results 51 to 60 of about 617,895 (318)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Effect of nitric oxide on postoperative acute kidney injury in patients who underwent cardiopulmonary bypass: a systematic review and meta-analysis with trial sequential analysis

Annals of Intensive Care, 2019
Background The effect of nitric oxide (NO) on renal function is controversial in critical illness. We performed a systematic meta-analysis and trial sequential analysis to determine the effect of NO gas on renal function and other clinical outcomes in ...
Jie Hu, Stefano Spina, Francesco Zadek, Nikolay O. Kamenshchikov, Edward A. Bittner, Juan Pedemonte, Lorenzo Berra   +6 more
doaj   +1 more source

Activation of D1 Dopamine Receptors Induces Emergence from Isoflurane General Anesthesia [PDF]

, 2012
Background: A recent study showed that methylphenidate induces emergence from isoflurane anesthesia. Methylphenidate inhibits dopamine and norepinephrine reuptake transporters.
Brown, Emery N., Chemali, Jessica J., Solt, Ken, Taylor, Norman E.   +3 more
core   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Possible iodophor-induced systemic iodine toxicity during transurethral seminal vesiculoscopy: a case report and literature review

BMC Urology
Rationale Iodophor, a disinfectant composed of iodine complexed with a surfactant, is extensively employed for preoperative skin preparation, burn wound management, and mucosal disinfection.
Meng Zhang, Nan Zhao, Huanhuan Zhang, Jianli Li   +3 more
doaj   +1 more source

Evaluation of Dental Treatments in Children Performed under General Anesthesia

Bezmiâlem Science, 2018
Objective:This retrospective study aimed to evaluate the characteristics and treatment modalities of children whose dental treatments were performed under general anesthesia.Methods:The records of 196 children (107 boys and 85 girls), who were treated by
Meltem BAKKAL
doaj   +1 more source

General Anesthesia, Sleep, and Coma [PDF]

New England Journal of Medicine, 2010
This review discusses the clinical and neurophysiological features of general anesthesia and their relationships to sleep and coma, focusing on the neural mechanisms of unconsciousness induced by selected intravenous anesthetic drugs.
Schiff, Nicholas D., Brown, Emery N., Lydic, Emily K.   +2 more
openaire   +4 more sources

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Cottonseed oil alleviates ischemic stroke injury by inhibiting the inflammatory activation of microglia and astrocyte

Journal of Neuroinflammation, 2020
Background Ischemic stroke is the second leading cause of death globally. The narrow time window for administering effective thrombolytic therapy motivates the search for alternative prevention strategies.
Min Liu, Zhipeng Xu, Long Wang, Lixia Zhang, Yi Liu, Jiangbei Cao, Qiang Fu, Yanhong Liu, Hao Li, Jingsheng Lou, Wugang Hou, Weidong Mi, Yulong Ma   +12 more
doaj   +1 more source

Anesthetic management in endovascular treatment of aortic pathologies [PDF]

, 2014
Objective: In this study we aimed to compare the anesthesia methods we used in the endovascular treatment of thoracic and abdominal aorta pathologies and to discuss accompanied by literature.
Abdulmenap Güzel, Erdal Doğan, Feyzi Çelik, Haktan Karaman, İlker Öngüç Aycan, Sinan Demirtaş, Taner Çiftçi   +6 more
core   +1 more source