Results 101 to 110 of about 4,521,682 (346)

Life as Complex Systems --- Viewpoint from Intra-Inter Dynamics [PDF]

open access: yesarXiv, 1998
Basic problems in complex systems are surveyed in connection with Life. As a key issue for complex systems, complementarity between syntax/rule/parts and semantics/behavior/whole is stressed. To address the issue, a constructive approach for a biological system is proposed.
arxiv  

Exposure to endosulfan can cause long term effects on general biology, including the reproductive system of mice. [PDF]

open access: yesFront Genet, 2022
Sharma A   +5 more
europepmc   +1 more source

The challenges of purely mechanistic models in biology and the minimum need for a 'mechanism-plus-X' framework [PDF]

open access: yes, 2018
Ever since the advent of molecular biology in the 1970s, mechanical models have become the dogma in the field, where a "true" understanding of any subject is equated to a mechanistic description. This has been to the detriment of the biomedical sciences,
Ehsani, Sepehr
core   +1 more source

Identification of novel small molecule inhibitors of ETS transcription factors

open access: yesFEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla   +9 more
wiley   +1 more source

On applications of Ulam-Hyers stability in biology and economics [PDF]

open access: yesarXiv, 2010
We argue that Ulam-Hyers stability concept is quite significant in realistic problems in numerical analysis, biology and economics. A generalization to nonlinear systems is proposed and applied to the logistic equation (both differential and difference), SIS epidemic model, Cournot model in economics and a reaction diffusion equation.
arxiv  

Underdetermination and Models in Biology [PDF]

open access: yes, 2017
Since the early 20th century underdetermination has been one of the most contentious problems in the philosophy of science. In this article I relate the underdetermination problem to models in biology and defend two main lines of argument: First, the use
Jedlička, Petr
core  

The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum

open access: yesFEBS Letters, EarlyView.
In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti   +3 more
wiley   +1 more source

Guidelines for benchmarking of optimization approaches for fitting mathematical models [PDF]

open access: yesarXiv, 2019
Insufficient performance of optimization approaches for fitting of mathematical models is still a major bottleneck in systems biology. In this manuscript, the reasons and methodological challenges are summarized as well as their impact in benchmark studies. Important aspects for increasing evidence of outcomes of benchmark analyses are discussed. Based
arxiv  

Social context prevents heat hormetic effects against mutagens during fish development

open access: yesFEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere   +5 more
wiley   +1 more source

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