Results 71 to 80 of about 11,347,707 (376)

Making tau amyloid models in vitro: a crucial and underestimated challenge

open access: yesFEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Development of General Biology Learning E-Modules Based on Constructivism

open access: yesScholaria: Jurnal Pendidikan dan Kebudayaan
Higher education must adapt its educational practices to ICT, which is now developed rapidly. There are many different approaches, and constructivism-based e-module development is an alternative.
Musma Rukmana   +4 more
doaj   +1 more source

THE BIOLOGICAL AND STRUCTURAL CHARACTERIZATION OF TRANSFERABLE BACTEROIDES R PLASMIDS [PDF]

open access: yes, 1979
In this literature review I will briefly describe the general biology of transferable antibiotic resistance in bacteria, the genetic elements involved (plasmids) and several specific plasmid associated phenotypes.
Welch, Rodney A.
core   +1 more source

General and Social Biology [PDF]

open access: yesNature, 1942
THE article by Mrs. S. Neville Rolfe in NATURE of January 24, p. 90, calls for comment and support. Does it occur to the average man that, except at some schools, everything taught is factual, with definite conclusions? For example, history, geography, grammar, mathematics, physics and chemistry all produce definite results. But when we enter the world
openaire   +2 more sources

Unconventional mRNA processing and degradation pathways for the polycistronic yrzI (spyTA) mRNA in Bacillus subtilis

open access: yesFEBS Letters, EarlyView.
The S1025 peptide is the major antidote to the YrzI toxin, which we renamed here as SpyT (Small Peptide YrzI Toxin) and SpyA (Small Peptide YrzI Antitoxin) (1). Degradation of the toxin–antitoxin spyTA mRNA, either by a translation‐dependent cleavage by the endoribonuclease Rae1 (2) or by direct attack by 3′‐exoribonucleases (3), also contributes to ...
Laetitia Gilet   +4 more
wiley   +1 more source

Quantum Biology [PDF]

open access: yesA. Sergi, Atti della Accademia Peloritana dei Pericolanti Vol. LXXXVII, C1C0901001 (2009), 2009
A critical assessment of the recent developments of molecular biology is presented. The thesis that they do not lead to a conceptual understanding of life and biological systems is defended. Maturana and Varela's concept of autopoiesis is briefly sketched and its logical circularity avoided by postulating the existence of underlying {\it living ...
arxiv   +1 more source

The solution supramolecular structure of α2 → 8 polysialic acid suggests a structural cause for its low immunogenicity

open access: yesFEBS Letters, EarlyView.
α2 → 8 polysialic acid elicits poor immunogenicity. Small‐angle scattering shows a supramolecular structure with parallel‐chain binding, although in different forms at μm and mm calcium. The major histocompatibility complex requires molecular weights around 2000 Da to produce antibodies, and 2000 Da polysialic oligomers will bind in these structures ...
Kenneth A. Rubinson
wiley   +1 more source

Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ imaging

open access: yesNature Communications, 2017
Tumour-associated macrophages (TAM) can be used as prognostic indicators in cancer. Here, the authors establish a platform for high-throughput 3D microscopy in murine lung carcinoma that allows to visualize TAMs infiltration throughout the entire lung ...
Michael F. Cuccarese   +7 more
doaj   +1 more source

Analogies Used in a General Biology Course: How is DNA Conserved Across Generations?

open access: yesJournal of Science Learning, 2023
The present study has two main goals. First, it aims to examine the analogies an instructor uses about "DNA conservation across generations" in a university-level General Biology course.
Nazlı Rüya Taşkın Bedizel   +1 more
doaj   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

open access: yesFEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto   +2 more
wiley   +1 more source

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