Results 51 to 60 of about 1,115,871 (358)

Influence of Doubled CO2 on Ozone via Changes in the Brewer–Dobson Circulation [PDF]

, 2007
In this short note, the effect of enhanced circulation due to doubling CO2 on ozone is investigated. The difference of Brewer–Dobson circulation (BDC) between the doubled CO2 and control run from an idealized atmospheric general circulation model is ...
Eichelberger, Scott J., Hartmann, Dennis L., Jiang, Xun, Shia, Runlie, Yung, Yuk L.   +4 more
core   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Evaluating the Applicability of a Quantile–Quantile Adjustment Approach for Downscaling Monthly GCM Projections to Site Scale over the Qinghai-Tibet Plateau

Atmosphere, 2021
In the context of global climate change, the Qinghai-Tibetan plateau (QTP) has experienced unprecedented changes in its local climate. While general circulation models (GCM) are able to forecast global-scale future climate change trends, further work ...
Ziyun Yin, Zhuotong Nan, Zetao Cao, Guofei Zhang   +3 more
doaj   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

A nested Atlantic-Mediterranean Sea general circulation model for operational forecasting [PDF]

Ocean Science, 2009
A new numerical general circulation ocean model for the Mediterranean Sea has been implemented nested within an Atlantic general circulation model within the framework of the Marine Environment and Security for the European Area project (MERSEA ...
P. Oddo, M. Adani, N. Pinardi, C. Fratianni, M. Tonani, D. Pettenuzzo   +5 more
doaj  

Modeling the oceanic general circulation

Eos, Transactions American Geophysical Union, 1986
An area of intense recent interest in physical oceanography and geophysical fluid dynamics is the theoretical and numerical analysis of the circulation of the oceans at planetary scales. While this has always been a tantalizing area, it has been a particularly active area in the last few years.
William K. Dewar, Peter B. Rhines
openaire   +1 more source

Effects of different closures for thickness diffusivity [PDF]

, 2009
The effects of spatial variations of the thickness diffusivity (K) appropriate to the parameterisation of [Gent, P.R. and McWilliams, J.C., 1990. Isopycnal mixing in ocean circulation models. J. Phys.
Danabasoglu, G., Eden, Carsten, Jochum, M.   +2 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source