Results 61 to 70 of about 1,124,157 (356)

Bayesian calibration of the Thermosphere-Ionosphere Electrodynamics General Circulation Model (TIE-GCM) [PDF]

Geoscientific Model Development, 2009
In this paper, we demonstrate a procedure for calibrating a complex computer simulation model having uncertain inputs and internal parameters, with application to the NCAR Thermosphere-Ionosphere-Electrodynamics General Circulation Model (TIE-GCM).
S. Guillas, J. Rougier, A. Maute, A. D. Richmond, C. D. Linkletter   +4 more
doaj  

Tropical Variability Simulated in ICON‐A With a Spectral Cumulus Parameterization

Journal of Advances in Modeling Earth Systems, 2020
We implemented a spectral cumulus parameterization based on a cloud‐resolving model (SC scheme) in the icosahedral nonhydrostatic atmospheric model (ICON‐A).
Yuya Baba, Marco A. Giorgetta
doaj   +1 more source

Weather-Layer Dynamics of Baroclinic Eddies and Multiple Jets in an Idealized General Circulation Model [PDF]

, 2008
The general circulation and the behavior of multiple jets and baroclinic eddies are described for an atmosphere in which meridional potential temperature gradients and eddies are confined to a weather layer.
O'Gorman, Paul A., Schneider, Tapio
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Neural general circulation models for modeling precipitation

Science Advances
General circulation models (GCMs) struggle to accurately simulate precipitation, particularly extremes and the diurnal cycle, which are crucial for both human activities and natural processes. Although hybrid models combining machine learning and physics offer a promising avenue to improve the simulation of precipitation, they have yet to outperform ...
Janni Yuval, Ian Langmore, Dmitrii Kochkov, Stephan Hoyer   +3 more
openaire   +3 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Climate Change Assessment Using Atmosphere-Ocean General Circulation Model) AOGCM( and Its Effect on Runoff Using HEC-HMS model [PDF]

, 2023
Abedi Koupai, J., Ali Reza Vahabi
openalex   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source