Results 61 to 70 of about 1,115,871 (358)

Bayesian calibration of the Thermosphere-Ionosphere Electrodynamics General Circulation Model (TIE-GCM) [PDF]

Geoscientific Model Development, 2009
In this paper, we demonstrate a procedure for calibrating a complex computer simulation model having uncertain inputs and internal parameters, with application to the NCAR Thermosphere-Ionosphere-Electrodynamics General Circulation Model (TIE-GCM).
S. Guillas, J. Rougier, A. Maute, A. D. Richmond, C. D. Linkletter   +4 more
doaj  

Tropical Variability Simulated in ICON‐A With a Spectral Cumulus Parameterization

Journal of Advances in Modeling Earth Systems, 2020
We implemented a spectral cumulus parameterization based on a cloud‐resolving model (SC scheme) in the icosahedral nonhydrostatic atmospheric model (ICON‐A).
Yuya Baba, Marco A. Giorgetta
doaj   +1 more source

Atmospheric circulation of hot Jupiters: Coupled radiative-dynamical general circulation model simulations of HD 189733b and HD 209458b [PDF]

, 2009
We present global, three-dimensional numerical simulations of HD 189733b and HD 209458b that couple the atmospheric dynamics to a realistic representation of non-gray cloud-free radiative transfer.
Ackerman, Adam P. Showman, Agol, Arakawa, Barman, Barman, Burrows, Burrows, Burrows, Chamberlain, Charbonneau, Cho, Cho, Cooper, Cooper, David Charbonneau, Deming, Dobbs-Dixon, Fortney, Fortney, Fortney, Fortney, Fortney, Freedman, Geballe, Goodman, Goody, Grillmair, Guillot, Heather A. Knutson, Hubeny, Jonathan J. Fortney, Knutson, Knutson, Langton, Langton, Leggett, Lian, Lodders, Lubow, Machalek, Mark S. Marley, Marley, Marley, Menou, Peixoto, Redfield, Richard S. Freedman, Salby, Saumon, Showman, Showman, Sing, Spiegel, Swain, Vasavada, Yuan Lian, Zahnle   +57 more
core   +3 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Breeding vectors and predictability in the Oxford Mars GCM [PDF]

, 2003
A breeding vectors approach is used to study the intrinsic predictability of the Martian atmosphere using the Oxford Mars General Circulation Model (MGCM).
Lewis, S.R., Newman, C.E., Read, P.L.
core  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Water vapor and the dynamics of climate changes [PDF]

, 2009
Water vapor is not only Earth's dominant greenhouse gas. Through the release of latent heat when it condenses, it also plays an active role in dynamic processes that shape the global circulation of the atmosphere and thus climate.
Adler, Allan, Allen, Arakawa, Bannon, Becker, Bengtsson, Bengtsson, Betts, Betts, Betts, Betts, Betts, Betts, Boer, Bordoni, Bosilovich, Brayshaw, Caballero, Caballero, Caballero, Caballero, Chang, Charney, Chen, Chou, Chou, Clement, Defant, Dickinson, Dima, Dima, Eady, Edmon, Emanuel, Emanuel, Emanuel, Emanuel, Emanuel, Fang, Folkins, Frierson, Frierson, Frierson, Frierson, Frierson, Geng, Graham, Gu, Gutowski, Held, Held, Held, Held, Held, Held, Held, Held, Herweijer, Hide, Hoffman, Hoskins, Hu, Iribarne, Jeffreys, Johanson, Juckes, Kiehl, Kim, Klinger, Knutson, Korty, Korty, Korty, Kushner, Kållberg, Lapeyre, Lee, Li, Lindzen, Lorenz, Lorenz, Lorenz, Lorenz, Lu, Neelin, Neelin, Neelin, Neelin, Neelin, O'Gorman, O'Gorman, O'Gorman, O'Gorman, O'Gorman, Orlanski, Otto-Bliesner, Paul A. O'Gorman, Peixoto, Pierrehumbert, Pierrehumbert, Previdi, Reed, Rind, Roads, Santer, Santer, Schneider, Schneider, Schneider, Schneider, Schneider, Schneider, Schneider, Schneider, Schneider, Schneider, Schneider, Seidel, Seidel, Seidel, Sherwood, Simmons, Simmons, Sobel, Stephens, Tanaka, Tapio Schneider, Thuburn, Trenberth, Trenberth, Trenberth, Trenberth, Trenberth, Trenberth, Uppala, Vecchi, Vecchi, Walker, Walker, Wentz, Wentz, Wernli, Willett, Xavier J. Levine, Yin, Zhang, Zurita-Gotor   +147 more
core   +3 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Climate Change Assessment Using Atmosphere-Ocean General Circulation Model) AOGCM( and Its Effect on Runoff Using HEC-HMS model [PDF]

, 2023
Jahangir Abedi Koupai, Ali Reza Vahabi
openalex   +1 more source