Results 71 to 80 of about 296,671 (297)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
, 2020 Data and software are nowadays one and the same: for this very reason, the European Union (EU) and other governments introduce frameworks for data protection — a key example being the General Data Protection Regulation (GDPR). However, GDPR compliance is
Damian A. Tamburri +3 more
core +1 more source
General Data Protection Regulation – results of a pilot study [PDF]
European Journal of Service Management, 2018 The article focuses on the social aspects of the GDPR implementation. Paper presents the results of a study conducted in 2018, after the introduction of legislative changes. The study was exploratory and its aim was to find out how administrative employees evaluated and feels about GDPR. The survey was conducted as an online survey questionnaire.
Czaplewski, Maciej +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
MANAGING INNOVATIVE COMPANY’S CAPITAL: THE CASE OF PERSONAL DATA TRANSFER
Zbornik Pravnog Fakulteta Sveučilišta u Rijeci, 2018 protection. The only case in which this issue could become more debatable is if personal data crosses EU borders. The transfer of personal data to third countries proved its disputed status when the CJEU invalidated the Safe Harbour Agreement, one of the
Danijela Vrbljanac
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Integrating Technical and Legal Concepts of Privacy
IEEE Access, 2018 We provide an overview of legal and technical concepts of privacy protection. Data protection guarantees exist in European Union at a primary law level since 2009, when the Lisbon Treaty has become effective.
Ana Sokolovska, Ljupco Kocarev
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
DPIA in Context: Applying DPIA to Assess Privacy Risks of Cyber Physical Systems
Future Internet, 2020 Cyber Physical Systems (CPS) seamlessly integrate physical objects with technology, thereby blurring the boundaries between the physical and virtual environments.
Jane Henriksen-Bulmer +2 more
doaj +1 more source