Results 81 to 90 of about 296,671 (297)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
OpenEHR Based Systems and the General Data Protection Regulation (GDPR) [PDF]
, 2018 The concerns about privacy and personal data protection resulted in reforms of the existing legislation in European Union (EU). The General Data Protection Regulation (GDPR) aims to reform the existing measures on the topic of personal data protection of
Correia, Ricardo Cruz +6 more
core +1 more source
An analysis of violations and sanctions following the GDPR
International Journal of Information Systems and Project Management, 2020 This paper investigates the violations and sanctions that have occurred following the implementation of the General Data Protection Regulation (GDPR). The GDPR came into effect in May 2018 with the aim of strengthening the information privacy of European
Wanda Kristiania University College +4 more
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
EU general data protection regulation: impact on data protection law.
, 2018 EU General Data Protection Regulation, which will come into force in 25 May 2018 will undoubtedly replace the existing practice of personal data protection.
Jakštaitė, Agnė,
core
Collectively exercising the right of access: individual effort, societal effect
Internet Policy Review, 2018 The debate about how to govern personal data has intensified in recent years. The European Union’s General Data Protection Regulation, which came into effect in May 2018, relies on transparency mechanisms codified through obligations for organisations ...
René L. P. Mahieu +2 more
doaj +1 more source
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
, 2022 This article analyzes, in a theoretical and practical way, the General Personal Data Regulation, which underpins the right of personal data subjects to lawful, fair, and transparent management and processing of their personal data, ensuring a high ...
Jagminaitė, Klaudija
core
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source