Results 61 to 70 of about 3,932,052 (308)

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Design and implementation of modular laparoscopic general surgery models for surgical education

Journal of Minimally Invasive Surgery
Appendectomy, cholecystectomy, and inguinal herniorrhaphy are fundamental procedures in general surgery. These surgeries help trainees develop essential surgical skills, including technical proficiency and surgical planning.
Sung Hyun Kim, Sang Sik Cho, In Geol Ho, Ho Seung Kim, Chang Moo Kang   +4 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Enhancing spatial perception in robot-assisted minimally invasive surgery with edge-preserving depth estimation and pose tracking

BMC Surgery
Background Enhancing the safety of robot-assisted minimally invasive surgery (RAMIS) is critically dependent on improving the robot’s spatial understanding of the surgical scene. However, the quality of laparoscopic images is often negatively affected by
Bo Guan, Jianchang Zhao, Bo Yi, Jianmin Li   +3 more
doaj   +1 more source

Dinar-Bademli Mosque: Architectural Characteristics and Hand-Made Decorations on Plaster

Megaron, 2020
Bademli Mosque, in Bademli village of Afyonkarahisar, dates back to the late Ottoman period. In Afyonkarahisar, as in many other Anatolian cities, the influence of this period is visible in the adorning of mosques.
Aslıhan Ece Paköz, Nurcan Boşdurmaz, Zeynep Gül Ünal   +2 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

It Better Only Drizzle, Why the newly created Oregon Rainy Day Fund is inadequate protection against the next economic downturn and how the problem can be fixed [PDF]

, 2007
Despite the creation of the Oregon Rainy Day Fund by the Legislature earlier this year, Oregon's public structures remain exposed to serious disruption in the next, inevitable economic downturn.
Charles Sheketoff, Michael Leachman
core  

RETHINKING DESIGN EDUCATION FOR THE MULTICULTURAL GENERATION

Design Conference Proceedings, 2018
The paper presents our strategies and insights for conducting a collaborative workshop of American and Chinese students and faculty in Guangzhou, China. Inspired by this experience, the authors address the challenges and opportunities of globalization and decolonization to design education.
Tao Huang, Aaron Scott, Qunxia Lu, Tingting Sui   +3 more
openaire   +2 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source