Results 71 to 80 of about 3,932,052 (308)

Curriculum 2000: implementation [PDF]

, 2003
This report offers a summary of findings of Ofsted’s survey work on the first two years of Curriculum 2000. The judgements are based on visits by eight of Her Majesty’s Inspectors (HMI) and 16 additional inspectors (AI) during 2000–2001, and by 13 HMI ...

core  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Scaffolding Critical Reflection in Online Discussions: Helping Prospective Teachers Think Deeply About Field Experiences in Urban Schools [PDF]

, 2003
A teacher educator uses the methodology of a design experiment to compare patterns and levels of reflection in two semesters of her students’ e-mail discussions about field experiences in urban schools.
Whipp, Joan
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Rates of Return to University Education: The Regression Discontinuity Design [PDF]

Estimating the rate of return to a university degree has always been difficult due to the problem of omitted variable biases. Benefiting from a special feature of the University Admission system in China, which has clear cutoffs for university entry ...
Fan, Elliott, Meng, Xin, Wei, Zhichao, Zhao, Guochang   +3 more
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Integrated learning: Ways of fostering the applicability of teachers’ pedagogical and psychological knowledge

Frontiers in Psychology, 2015
In teacher education, general pedagogical and psychological knowledge is often taught separately from the teaching subject itself, potentially leading to inert knowledge.
Nora eHarr, Andreas eEichler, Alexander eRenkl   +2 more
doaj   +1 more source

Research and Development of Immersive Computational Thinking Tools using Virtual Reality, Natural Hazards Data, and Scientific Visualization to Engage K-12 Students in Scientific Computing and Engineering Education [PDF]

, 2019
The NHERI DesignSafe-CI Research Experience for Teachers (RET) supplement recruits two high school teachers to work alongside faculty, researchers, and staff of the Texas Advanced Computing Center (TACC) at The University of Texas at Austin.
Garza, Edgar, Marquez, Jessica, Van Houten, Katrina   +2 more
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Instance-level semantic segmentation of nuclei based on multimodal structure encoding

BMC Bioinformatics
Background Accurate segmentation and classification of cell nuclei are crucial for histopathological image analysis. However, existing deep neural network-based methods often struggle to capture complex morphological features and global spatial ...
Bo Guan, Guangdi Chu, Ziying Wang, Jianmin Li, Bo Yi   +4 more
doaj   +1 more source

LIFT: 21st century health care centres [PDF]

, 2006
Purpose To examine the processes used to procure and develop new primary health care premises in the United Kingdom and in particular the use of the private finance initiative and related methods.
Capper, Graham, Holmes, John, Hudson, Gordon   +2 more
core   +1 more source