Results 81 to 90 of about 3,932,052 (308)

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Multi-source data based refined transient modelling and analysis method for thermal performance of precision machine tool feed system

Case Studies in Thermal Engineering
Variation in feed speed, acceleration, preload and other parameters significantly influence the inertia loss torque and friction torque within the feed system of machine tool.
Yingjie Zheng, Lingtao Weng, Yuhong Dai, Yutao Fu, Kai Shi, Zheng Wang, Weiguo Gao, Dawei Zhang, Tian Huang   +8 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Educational Tools to Introduce Computer-Aided Drug Design to Students and to the Public at Large

CHIMIA, 2018
The Drug Design Workshop initiative was put in place in 2015 and consists of a collection of educational tools especially developed to introduce computer-aided drug design to the general public and students of various levels. These presentations,
Antoine Daina, Marie-Claude Blatter, Vivienne Baillie Gerritsen, Vincent Zoete   +3 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Integrating Universal Design and Response to Intervention in Methods Courses for General Education Mathematics Teachers

Journal of Mathematics Education at Teachers College, 2014
Traditionally, teacher education programs have placed little emphasis on preparing mathematics teachers to work with students who struggle in mathematics. Therefore, it is crucial that mathematics teacher educators explicitly prepare prospective teachers
Kelley Buchheister, Christa Jackson, Cynthia E. Taylor   +2 more
doaj   +3 more sources

Fashion Design:Facilitating Generational Change [PDF]

, 2018
There is greater need for interrogation of the modus operandi of the fashion and textile design industries, but the contention in this article is there is the same need for an interrogation of sustainability, ethics, diversity and inclusion as core ...
Ballie, Jennifer, Valentine, Louise
core   +2 more sources

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Immersive Experience in Design: Participatory Practices of Audience Cultural Identity and Memory Construction

Arts
Immersive theatre, as a contemporary performance form that integrates narrative, space, and sensory participation, has gradually expanded from entertainment consumption to a practice of cultural representation and memory construction.
Man-Ting Ku, Shang-Chia Chiou, Hsin-Te Chan   +2 more
doaj   +1 more source

The effect of a cardiovascular risk factor education program on health behaviors of selected school age children [PDF]

, 1987
This study, using a quasi-experimental design, was conducted to explore the effect of a cardiovascular risk factor education program on the health behaviors of a group of fifth grade children.
Tuck, Terry M., Williams, Sharon K.
core   +1 more source