Results 41 to 50 of about 5,891 (239)
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
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A general technique for fast comprehensive multi-root planning on graphs by coloring vertices and deferring edges [PDF]
2015 IEEE International Conference on Robotics and Automation (ICRA), 2015 We formulate and study the comprehensive multi-root (CMR) planning problem, in which feasible paths are desired between multiple regions. We propose two primary contributions which allow us to extend state-of-the-art sampling-based planners. First, we propose the notion of vertex coloring as a compact representation of the CMR objective on graphs ...
Christopher M. Dellin +1 more
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Three-Edge-Coloring Projective Planar Cubic Graphs: A Generalization of the Four Color Theorem
2024 IEEE 65th Annual Symposium on Foundations of Computer Science (FOCS)We prove that every cyclically 4-edge-connected cubic graph that can be embedded in the projective plane, with the single exception of the Petersen graph, is 3-edge-colorable. In other words, the only (non-trivial) snark that can be embedded in the projective plane is the Petersen graph.
Yuta Inoue +4 more
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
IEEE AccessLet $G(V,E)$ be a simple, non-trivial, connected graph with vertex set $V(G)$ and edge set $E(G)$ . A vertex coloring $c: V(G) \to \mathbb {N}$ of $G$ is called a sigma coloring if $\sigma (u) \neq \sigma (v)$ for all $uv\in E(G)$ , where ...
C. Yogalakshmi, B. J. Balamurugan
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Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
The Strong Chromatic Index of Complete Halin Graphs
MathematicsThe strong edge coloring of a graph G is an assignment of colors to the edges of G such that two distinct edges are colored differently if they are incident to a common edge or share an endpoint. The strong chromatic index of a graph G, denoted by χs′(G),
Zhiwei Bi, Yunfang Tang
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source