Results 91 to 100 of about 7,283,680 (307)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Sustainability: Teaching an Interdisciplinary Threshold Concept through Traditional Lecture and Active Learning

Canadian Journal for the Scholarship of Teaching and Learning, 2015
One of the difficulties in teaching global sustainability in the introductory political science classes is the different emphases placed on this concept and the absence of the consensus on where the overall balance between environmental protection ...
Ekaterina M. Levintova, Daniel W. Mueller   +1 more
doaj  

Das Problem der Allgemeinbildung geschichtlich betrachtet

Paedagogia Christiana, 2014
Problem kształcenia ogólnego z perspektywy historycznej(Streszczenie)Przeobrażanie się terminu „encyklopedia“ stanowi odzwierciedlenie historycznego postępu wiedzy i zmian w edukacji.
Gunter Scholtz
doaj   +1 more source

City and Islington College (FEFC inspection report; 75/97 and 31/01) [PDF]

, 2001
Comprises two Further Education Funding Council (FEFC) inspection reports for the periods 1996-97 (75/97), and 2000-01 (31/01). The FEFC has a legal duty to make sure further education in England is properly assessed.

core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Development and validation of an instrument to collect students’ perceptions of upper secondary education programmes

Educar
This article details the design and validation of the Students’ Perceptions of Upper Secondary Education Programmes (SPUSEP) instrument, developed to explore Portuguese students’ experiences of transitioning into upper secondary education.
Ana Cristina Torres
doaj   +1 more source

Innovative experiential learning experience: Pedagogical adopting Kolb’s learning cycle at higher education in Hong Kong

Cogent Education, 2019
General education constitutes a significant portion of undergraduate curriculum. However, students are not always keen on learning general education.
Shui Kau Chiu
doaj   +1 more source

Hands‐on protocol for preparing water‐soluble fractions from agri‐food samples for NMR‐based metabolomics analysis

FEBS Open Bio, EarlyView.
This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso, Jaime Hiniesta‐Valero, Alejandra Guerra‐Castellano, Miguel A. De la Rosa, Irene Díaz‐Moreno   +4 more
wiley   +1 more source

Development and construction of China [PDF]

, 2008
Libraries in China's higher education institutions have been developing in keeping pace with the flourishing development of China's higher education.
DAI Longji, Dai Longji (E-mail: dailj@lib.pku.edu.cn), SONG Jiao, SONG Xue, YAN Jinwei, ZHANG Yan, ZHENG Lan   +6 more
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SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source