Results 111 to 120 of about 3,454,963 (308)

Environmental health discipline science plan [PDF]

The purpose of this plan is to provide a conceptual strategy for NASA's Life Sciences Division research and development activities in environmental health.

core   +1 more source

La relevancia de la educación científica : actitudes y valores de los estudiantes relacionados con la ciencia y la tecnología [PDF]

, 2009
La relevancia de la educación científica (ROSE) es un programa internacional de investigación comparativa basado en un cuestionario que explora los factores afectivos de la educación científica desde la perspectiva de los que aprenden.
Manassero Mas, María Antonia, Vázquez Alonso, Ángel   +1 more
core   +2 more sources

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Method for long-term room temperature storage of mouse freeze-dried sperm

Scientific Reports
Permanent preservation of genetic resources may be indispensable for the future of humanity. This requires liquid nitrogen, as is the case for preserving animal sperm.
Yuko Kamada, Kango Yamaji, Natsuki Ushigome, Daiyu Ito, Sayaka Wakayama, Kenichiro Hiraoka, Masaru Hayashi, Kiyotaka Kawai, Teruhiko Wakayama   +8 more
doaj   +1 more source

Poor alignment of priorities between scientists and policymakers highlights the need for evidence-informed conservation in Brazil

Perspectives in Ecology and Conservation, 2018
There is a worldwide claim by environmentalists and scientists that environmental policy usually lacks support based on scientific evidence. In this work we studied the gap between science and conservation actions in Brazil.
Manoela Karam-Gemael, Rafael Loyola, Jerry Penha, Thiago Izzo   +3 more
doaj   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

The C-value enigma and timing of the Cambrian explosion

, 2008
The Cambrian explosion is a grand challenge to science today and involves multidisciplinary study. This event is generally believed as a result of genetic innovations, environmental factors and ecological interactions, even though there are many ...
Adami, Bousso, Bromham, Carter, Conway Morris, Davidson, Davidson, Dirson Jian Li, Gregory, Hedges, Kauffman, Knoll, Knoll, Kumar, Larroux, Li, Li, Lynch, Mattick, Mattick, Mojzsis, Peltier, Peterson, Sharov, Shengli Zhang, Shmulevich, Shu, Trevors, Valentine, Wada   +29 more
core   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

The Implementation of Science, Technology and Society Environment (STSE)-Based Learning for Developing Pre-Service General Science Teachers’ Understanding of the Nature of Science by Empirical Evidence

Jurnal Pendidikan IPA Indonesia, 2019
The objective of this research was to study the outcomes of teaching method based on Science, Technology, Society, and Environment (STSE) in enhancing the nature of science understanding, emphasizing the empirical evidence among 23 pre-service general ...
S. Gathong, S. Chamrat
doaj   +1 more source