Results 121 to 130 of about 3,463,591 (310)

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Poor alignment of priorities between scientists and policymakers highlights the need for evidence-informed conservation in Brazil

Perspectives in Ecology and Conservation, 2018
There is a worldwide claim by environmentalists and scientists that environmental policy usually lacks support based on scientific evidence. In this work we studied the gap between science and conservation actions in Brazil.
Manoela Karam-Gemael, Rafael Loyola, Jerry Penha, Thiago Izzo   +3 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Assessing the quality of generative artificial intelligence for science communication in environmental research

Abstract The adoption of Generative Artificial Intelligence (GenAI) tools is drastically changing the way that researchers work. While debate on the quality of GenAI outputs continues, there is optimism that GenAI may help human experts to address the most significant environmental challenges facing society.
David Worden, Daniel Richards
openaire   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

The Implementation of Science, Technology and Society Environment (STSE)-Based Learning for Developing Pre-Service General Science Teachers’ Understanding of the Nature of Science by Empirical Evidence

Jurnal Pendidikan IPA Indonesia, 2019
The objective of this research was to study the outcomes of teaching method based on Science, Technology, Society, and Environment (STSE) in enhancing the nature of science understanding, emphasizing the empirical evidence among 23 pre-service general ...
S. Gathong, S. Chamrat
doaj   +1 more source

Vulnerability : a view from different disciplines [PDF]

Practitioners from different disciplines use different meanings and concepts of vulnerability, which, in turn, have led to diverse methods of measuring it.
Alwang, Jeffrey, Jorgensen, Steen L., Siegel, Paul B.   +2 more
core  

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

The Role of the World Bank in Controlling Corruption [PDF]

, 1997
In 1997, Professor of Law and Political Science, Susan Rose-Ackerman of Yale University, delivered the Georgetown Law Center’s seventeenth Annual Philip A. Hart Memorial Lecture: The World Bank’s Role in Controlling Corruption.
Rose-Ackerman, Susan
core   +1 more source

The C-value enigma and timing of the Cambrian explosion

, 2008
The Cambrian explosion is a grand challenge to science today and involves multidisciplinary study. This event is generally believed as a result of genetic innovations, environmental factors and ecological interactions, even though there are many ...
Adami, Bousso, Bromham, Carter, Conway Morris, Davidson, Davidson, Dirson Jian Li, Gregory, Hedges, Kauffman, Knoll, Knoll, Kumar, Larroux, Li, Li, Lynch, Mattick, Mattick, Mojzsis, Peltier, Peterson, Sharov, Shengli Zhang, Shmulevich, Shu, Trevors, Valentine, Wada   +29 more
core   +1 more source